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dc.contributor.author
Blanco, Pablo Javier
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dc.contributor.author
Santos, Gabriela H. Vargas dos
dc.contributor.author
Bulant, Carlos Alberto
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dc.contributor.author
Alvarez, Alonso M.
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Oliveira, Fredric A. P.
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Cunha Lima, Gabriella
dc.contributor.author
Lemos, Pedro A.
dc.date.available
2022-08-05T15:02:20Z
dc.date.issued
2022-01
dc.identifier.citation
Blanco, Pablo Javier; Santos, Gabriela H. Vargas dos; Bulant, Carlos Alberto; Alvarez, Alonso M.; Oliveira, Fredric A. P.; et al.; Scaling laws and the left main coronary artery bifurcation: a combination of geometric and simulation analyses; Elsevier; Medical Engineering & Physics; 99; 1-2022; 1-32
dc.identifier.issn
1350-4533
dc.identifier.uri
http://hdl.handle.net/11336/164375
dc.description.abstract
The geometry of coronary arteries is believed to play the role as an atherosclerotic risk factor on its own. The full characterization of the normal coronary network has been reported in the literature. Reports on the integration of geometry and functional data for normal coronary vessels started to proliferate more recently. In this work, we analyze and integrate the geometric data retrieved from angiography images of the left main coronary bifurcation in angiographically normal patients and hemodynamic data generated from blood flow models to analyze the role of allometric laws and the connection between flow distribution and wall shear stress loads on the left anterior descending and left circumflex arteries. This in-silico study contributes to the characterization of normal coronary anatomy and its impact on the hemodynamic shear stresses acting over the vessel wall, shedding light on the impact of geometry-based versus simulation-based hypotheses to define boundary conditions for numerical simulations. We discuss the role of the wall shear stress corresponding to scenarios adopted by the scientific community and the ones proposed in this study. For the simulation-based hypothesis, we propose an iterative strategy to define boundary conditions at the main left coronary bifurcation, such that wall shear stresses are matched between the left descending and left circumflex arteries. From this study, we conclude that a one-fits-all power law exponent of results in an good trade-off between computational cost and wall shear stress balance between daughter vessels.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
ALLOMETRIC LAWS
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ANGIOGRAPHY
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BLOOD FLOW
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CORONARY ARTERIES
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SIMULATION
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VASCULAR GEOMETRY
dc.subject.classification
Ingeniería Médica
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dc.subject.classification
Ingeniería Médica
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dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
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dc.title
Scaling laws and the left main coronary artery bifurcation: a combination of geometric and simulation analyses
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-08-04T15:08:48Z
dc.journal.volume
99
dc.journal.pagination
1-32
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Ámsterdam
dc.description.fil
Fil: Blanco, Pablo Javier. National Laboratory for Scientific Computing; Brasil. National Institute of Science and Technology in Medicine; Brasil
dc.description.fil
Fil: Santos, Gabriela H. Vargas dos. Hospital Israelita Albert Einstein; Brasil
dc.description.fil
Fil: Bulant, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil; Argentina. National Institute of Science and Technology in Medicine; Brasil
dc.description.fil
Fil: Alvarez, Alonso M.. National Laboratory for Scientific Computing; Brasil. National Institute of Science and Technology in Medicine; Brasil
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Fil: Oliveira, Fredric A. P.. Hospital Israelita Albert Einstein; Brasil
dc.description.fil
Fil: Cunha Lima, Gabriella. Hospital Israelita Albert Einstein; Brasil
dc.description.fil
Fil: Lemos, Pedro A.. Hospital Israelita Albert Einstein; Brasil. University of São Paulo Medical School. Heart Institute. Department of Interventional Cardiology; Brasil. National Institute of Science and Technology in Medicine; Brasil
dc.journal.title
Medical Engineering & Physics
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1350453321001016
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.medengphy.2021.08.011
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