Artículo
The rs4712527 Polymorphism in the CDKAL1 Gene: A protective factor for proliferative diabetic retinopathy progress in type 2 diabetes
Yang, Pablo
; Luna, José Domingo; Alcoba, Emilio; Sein, Aylén; Gramajo, Ana Laura
; Juárez, Claudio P.; Beltramo, Dante Miguel
; Soria, Néstor Walter
Fecha de publicación:
05/2018
Editorial:
SAGE Publications
Revista:
Journal of VitreoRetinal Diseases
ISSN:
2474-1264
e-ISSN:
2474-1272
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Purpose: Diabetic retinopathy (DR) is one of the chronic retinal disorders linked to diabetes and remains the leading cause of blindness in working-age people. Many studies have demonstrated the existence of associations between type 2 diabetes mellitus (T2DM) and variants in the cyclin-dependent kinase 5 regulatory subunit?associated protein 1-like 1 (CDKAL1) gene. Here, weperformed a case-control study in the CDKAL1 gene (rs4712527 polymorphism) to investigate the potential association between this single-nucleotide polymorphism (SNP) and DR risk. Methods: Two hundred thirty-one patients with T2DM (126 patients with proliferative diabetic retinopathy [PDR] and 105 patients without diabetic retinopathy [WDR]), who assisted at the CentroPrivado de Ojos Romagosa, Fundacio´n VER, were studied. An independent cohort of 98 patients (56 with PDR and 42 with WDR) from the Hospital Nacional de Clı´nicas was taken for replication. A complete ophthalmological examination included an externalexamination of the eye and adnexa, pupil responsiveness, and slit-lamp biomicroscopic examination. Genotyping of rs4712527 was carried out by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The odds ratio (OR) and 95% CI were calculated by unconditional logistic regression adjusted for diabetes duration, body mass index, insulin therapy,HbA1c, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, and systolic and diastolic blood pressure. Results: Analysis from the rs4712527 SNP in the Centro Privado de Ojos Romagosa, Fundacio´n VER, cohort was found to be associated with decreased risk of PDR both before and after adjustment, under the codominant (adjustedOR ¼ 0.16 [95% CI, 0.06-0.44]; P ¼ 4e-04), dominant (adjusted OR ¼ 0.17 [95% CI, 0.07-0.43]; P ¼ 1e-04), overdominant (adjusted OR ¼ 0.20 [95% CI, 0.08-0.52]; P ¼ 5e-04), and log-additive (adjusted OR ¼ 0.28 [95% CI, 0.13-0.59]; P ¼ 4e-04)models. In the combined analysis including both cohorts, the rs4712527 was nominally involved as a protective factor in the development of DR. Conclusions: Our findings suggest that the rs4712527 in the CDKAL1 gene might be involved in the protection to develop PDR in T2DM.
Palabras clave:
CDKAL1 GENE
,
POLYMORPHISM
,
RS4712527
,
DIABETIC RETINOPATHY
,
TYPE 2 DIABETES
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CCT - CORDOBA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Citación
Yang, Pablo; Luna, José Domingo; Alcoba, Emilio; Sein, Aylén; Gramajo, Ana Laura; et al.; The rs4712527 Polymorphism in the CDKAL1 Gene: A protective factor for proliferative diabetic retinopathy progress in type 2 diabetes; SAGE Publications; Journal of VitreoRetinal Diseases; 2; 4; 5-2018; 1-8
Compartir
Altmétricas