Artículo
Heat Shock Proteins 90 kDa: Immunomodulators and Adjuvants in Vaccine Design Against Infectious Diseases
Corigliano, Mariana Georgina
; Sander, Valeria Analia
; Sánchez López, Edwin Fernando
; Ramos Duarte, Víctor Andrés
; Mendoza Morales, Luisa Fernanda
; Angel, Sergio Oscar
; Clemente, Marina
Fecha de publicación:
01/2021
Editorial:
Frontiers Media
Revista:
Frontiers in Bioengineering and Biotechnology
ISSN:
2296-4185
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Heat shock proteins 90 kDa (Hsp90s) were originally identified as stress-responsive proteins and described to participate in several homeostatic processes. Additionally, extracellular Hsp90s have the ability to bind to surface receptors and activate cellular functions related to immune response (cytokine secretion, cell maturation, and antigen presentation), making them very attractive to be studied as immunomodulators. In this context, Hsp90s are proposed as new adjuvants in the design of novel vaccine formulations that require the induction of a cell-mediated immune response to prevent infectious diseases. In this review, we summarized the adjuvant properties of Hsp90s when they are either alone, complexed, or fused to a peptide to add light to the knowledge of Hsp90s as carriers and adjuvants in the design of vaccines against infectious diseases. Besides, we also discuss the mechanisms by which Hsp90s activate and modulate professional antigen-presenting cells.
Palabras clave:
CARRIER
,
CHAPERONES
,
CROSS-PRESENTATION
,
GP96
,
GRP94
,
HSP90
,
MHC CLASS I
,
RE-PRESENTATION
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Colecciones
Articulos(CCT - LA PLATA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Citación
Corigliano, Mariana Georgina; Sander, Valeria Analia; Sánchez López, Edwin Fernando; Ramos Duarte, Víctor Andrés; Mendoza Morales, Luisa Fernanda; et al.; Heat Shock Proteins 90 kDa: Immunomodulators and Adjuvants in Vaccine Design Against Infectious Diseases; Frontiers Media; Frontiers in Bioengineering and Biotechnology; 8; 622186; 1-2021; 1-19
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