Artículo
The dopamine receptor agonist apomorphine stabilizes neurotoxic α-synuclein oligomers
de Araujo Lima, Vanderlei; Esquinelato, Rodrigo; Do Carmo Goncalves, Phelippe
; do Nascimento, Lucas Alex; Lee, Hudson; Eliezer, David; Romão, Luciana; Follmer, Cristian
![Icon](/themes/CONICETDigital/images/conicet.png)
Fecha de publicación:
02/2022
Editorial:
John Wiley & Sons Inc.
Revista:
FEBS Letters
ISSN:
0014-5793
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The misfolding and aggregation of the protein α-synuclein (aSyn) into potentially neurotoxic oligomers is believed to play a pivotal role in the neuropathogenesis of Parkinson’s disease (PD). Herein, we explore how apomorphine (Apo), a nonselective dopamine D1 and D2 receptor agonist utilized in the therapy for PD, affects the aggregation and toxicity of aSyn in vitro. Our data indicated that Apo inhibits aSyn fibrillation leading to the formation of large oligomeric species (Apo-aSyn-O), which exhibit remarkable toxicity in mesencephalic dopaminergic neurons in primary cultures. Interestingly, purified Apo-aSyn-O, even at very low concentrations, seems to be capable of converting unmodified aSyn monomer into neurotoxic species. Collectively, our findings warn for a possible dangerous effect of Apo on aSyn misfolding/aggregation pathway.
Palabras clave:
APOMORPHINE
,
DOPAMINE
,
NEUROTOXICITY
,
OLIGOMER
,
PARKINSON´S DISEASE
,
Α-SYNUCLEIN
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Articulos(CCT - ROSARIO)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - ROSARIO
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - ROSARIO
Citación
de Araujo Lima, Vanderlei ; Esquinelato, Rodrigo; Do Carmo Goncalves, Phelippe; do Nascimento, Lucas Alex; Lee, Hudson; et al.; The dopamine receptor agonist apomorphine stabilizes neurotoxic α-synuclein oligomers; John Wiley & Sons Inc.; FEBS Letters; 596; 3; 2-2022; 309-322
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