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Artículo

How the external solvent in biocompatible reverse micelles can improve the alkaline phosphatase behavior

Dib, NahirIcon ; Girardi, Valeria RominaIcon ; Silber, Juana J.; Correa, Nestor MarianoIcon ; Falcone, Ruben DarioIcon
Fecha de publicación: 06/2021
Editorial: Royal Society of Chemistry
Revista: Organic & Biomolecular Chemistry
ISSN: 1477-0520
e-ISSN: 1477-0539
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Físico-Química, Ciencia de los Polímeros, Electroquímica

Resumen

In the last decade, the nature of the nonpolar solvents that can be part of reverse micelles (RMs) has been the topic of several investigations to improve their applications. In this sense, the hydrolysis of 1-naphthyl phosphate catalyzed by the enzyme alkaline phosphatase (AP) was used as a probe to investigate the effect of the change of the external solvent on RMs formulated with the anionic surfactant sodium diethylhexyl sulfosuccinate (AOT). As external nonpolar solvents, two biocompatible lipophilic esters, isopropyl myristate and methyl laurate, and the traditional nonpolar solvents,n-heptane and benzene, were used. The results were compared among the RMs investigated and with the reaction in homogeneous media. Thus, the effect of the nanoconfinement as well as the impact of the replacement of a conventional external nonpolar solvent by biocompatible solvents were analyzed. The results indicate that the catalytic efficiency in the AOT RMs is larger than that in homogeneous media, denoting a different hydration level over the AP enzyme, which is directly related to the different degrees of nonpolar solvent penetration to the RM interface. Our findings demonstrated that toxic solvents such asn-heptane and benzene can be replaced by nontoxic ones (isopropyl myristate or methyl laurate) in AOT RMs without affecting the performance of micellar systems as nanoreactors, making them a green and promising alternative toward efficient and sustainable chemistry.
Palabras clave: SOLVENT EFFECTS , CONFINEMENT , REVERSE MICELLES , GREN CHEMISTRY
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/164012
DOI: http://dx.doi.org/10.1039/d0ob02371j
URL: https://pubs.rsc.org/en/content/articlelanding/2021/OB/D0OB02371J
Colecciones
Articulos (IDAS)
Articulos de INSTITUTO PARA EL DESARROLLO AGROINDUSTRIAL Y DE LA SALUD
Articulos(CCT - CORDOBA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Citación
Dib, Nahir; Girardi, Valeria Romina; Silber, Juana J.; Correa, Nestor Mariano; Falcone, Ruben Dario; How the external solvent in biocompatible reverse micelles can improve the alkaline phosphatase behavior; Royal Society of Chemistry; Organic & Biomolecular Chemistry; 19; 22; 6-2021; 4969-4977
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