Artículo
Autoantibodies against cerebral muscarinic cholinoceptors in Sjögren syndrome: Functional and pathological implications
Fecha de publicación:
05/2004
Editorial:
Elsevier Science
Revista:
Journal of Neuroimmunology
ISSN:
0165-5728
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Previous studies have demonstrated that antibodies against muscarinic acetylcholine receptors (mAChRs) from exocrine glands, correlates with Sjögren syndrome (SS) in the majority of patients. The aim of the present investigation was to establish if serum IgG antibodies present in SS interacts with cerebral mAChRs. Results show that anti-cerebral IgG are present in the sera of 40% SS patients studied. Autoantibodies were able to interact with mAChRs of cerebral frontal cortex membranes inhibiting the [(3)H]QNB binding to its specific receptor. Moreover, tested by ELISA and dot blot they recognized the synthetic peptides corresponding to the second extracellular loop of human M(1) and M(3) mAChR. In addition, the corresponding affinity-purified anti-M(1) and anti-M(3) peptide IgGs displayed an agonistic activity, stimulating phosphoinositide hydrolysis. The results support the notion that serum IgG autoantibodies in SS patients target cerebral mAChRs may have some role in the pathogenesis of higher cognitive dysfunction present in SS patients.
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Reina, Silvia Lorena; Sterin Borda, Leonor; Orman, Betina; Borda, Enri Santiago; Autoantibodies against cerebral muscarinic cholinoceptors in Sjögren syndrome: Functional and pathological implications; Elsevier Science; Journal of Neuroimmunology; 150; 1-2; 5-2004; 107-115
Compartir
Altmétricas