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dc.contributor.author
Ossola, César Ángel
dc.contributor.author
Surkin, Pablo Nicolas
dc.contributor.author
Pugnaloni, Antonela
dc.contributor.author
Mohn, Claudia Ester
dc.contributor.author
Elverdin, Juan Carlos
dc.contributor.author
Fernández Solari, Jose Javier
dc.date.available
2017-05-12T16:00:29Z
dc.date.issued
2012-09
dc.identifier.citation
Ossola, César Ángel; Surkin, Pablo Nicolas; Pugnaloni, Antonela; Mohn, Claudia Ester; Elverdin, Juan Carlos; et al.; Long-term treatment with methanandamide attenuates LPS-induced periodontitis in rats; Birkhauser Verlag Ag; Inflammation Research; 61; 9; 9-2012; 941-948
dc.identifier.issn
1023-3830
dc.identifier.uri
http://hdl.handle.net/11336/16385
dc.description.abstract
OBJECTIVE: Evidence exists of the anti-inflammatory and immunological properties of endocannabinoids in various tissues; the aim of the present study was therefore to assess the effect of long-term treatment with the synthetic cannabinoid methanandamide (Meth-AEA) on the progression of periodontitis in rats. MATERIALS AND METHODS: Periodontitis was induced by injecting LPS (1 mg/ml) into the gingiva around the neck of the first upper and lower molars, and into the inter-dental space between the first and second molars. This protocol was repeated for 6 weeks on days 1, 3, and 5 of each week. RESULTS: Long-term treatment with topical Meth-AEA (500 ng/ml), applied daily to gingival tissue of rats induced with periodontitis, significantly diminished the alveolar bone loss, measured as the distance between the cemento-enamel junction and the alveolar crest, in both maxillary and mandibular first molars, compared to rats without treatment (P < 0.05). The treatment also reduced the production of some biological mediators of periodontal disease augmented by LPS, such as tumor necrosis factor alpha (from 119.4 ± 9.9 pg/mg protein to 75.1 ± 10.8, P < 0.05) and nitric oxide produced by inducible nitric oxide synthase (from 507.7 ± 107.1 pmol/min/mg protein to 163.1 ± 53.9, P < 0.01). CONCLUSION: These results demonstrate the beneficial effects of treatment with Meth-AEA on gingival tissue of rats with periodontitis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Birkhauser Verlag Ag
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Oxygen Radicals
dc.subject
Lipopolysaccharide
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Bone Injury
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Tumor Necrosis Factor
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Prostaglandins
dc.subject.classification
Fisiología
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Long-term treatment with methanandamide attenuates LPS-induced periodontitis in rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-05-10T19:59:04Z
dc.identifier.eissn
1420-908X
dc.journal.volume
61
dc.journal.number
9
dc.journal.pagination
941-948
dc.journal.pais
Suiza
dc.journal.ciudad
Basilea
dc.description.fil
Fil: Ossola, César Ángel. Universidad de Buenos Aires. Facultad de Odontología; Argentina
dc.description.fil
Fil: Surkin, Pablo Nicolas. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Pugnaloni, Antonela. Universidad de Buenos Aires. Facultad de Odontología; Argentina
dc.description.fil
Fil: Mohn, Claudia Ester. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Elverdin, Juan Carlos. Universidad de Buenos Aires. Facultad de Odontología; Argentina
dc.description.fil
Fil: Fernández Solari, Jose Javier. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Inflammation Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00011-012-0485-z
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00011-012-0485-z
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