Novel poly(NIPA-co-AAc) functional hydrogels with potential application in drug controlled release

The synthesis, characterization and properties of pH/thermosensitive hydrogels based on acrylic acid (AAc) and N-isopropylacrylamide (NIPA) using (+)-N,N′-diallyltartramide (DAT) as cross-linking agent and water as solvent, are presented in this article. Subsequently, the incorporation of ofloxacin (OFL) as model drug to evaluate the drug load capacity of hydrogels and the in vitro release from OFL-polymer conjugate are presented in order to define potential pharmaceutical applications. Interestingly, the incorporation of AAc diversified the properties of NIPA-based hydrogels allowing ionic interaction of these new materials with drugs of opposite charge and produced different release profiles at pH 1.2 and 6.8 simulated physiological media.

Palabras clave: BIOMEDICAL POLYMERS , DRUG DELIVERY , HYDROGELS , POLYMERIC GELS , SMART FORMULATIONS

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

Identificadores

URI: http://hdl.handle.net/11336/16375

URL: http://pubs.acs.org/doi/full/10.1021/mp400615n

DOI: http://dx.doi.org/10.1021/mp400615n

Colecciones

Articulos(CIBICI)
Articulos de CENTRO DE INV.EN BIOQUI.CLINICA E INMUNOLOGIA

Articulos(IMBIV)
Articulos de INST.MULTIDISCIPL.DE BIOLOGIA VEGETAL (P)

Articulos(UNITEFA)
Articulos de UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA

Citación

Cuggino, Julio César; Contreras, Cintia Belén; Jimenez Kairuz, Alvaro Federico; Maletto, Belkys Angélica; Alvarez Igarzabal, Cecilia Ines; Novel poly(NIPA-co-AAc) functional hydrogels with potential application in drug controlled release; American Chemical Society; Molecular Pharmaceutics; 11; 7; 5-2014; 2239-2249

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