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dc.contributor.author
Brekhman, Vera
dc.contributor.author
Ofek Lalzar, Maya
dc.contributor.author
Atkinson, Stephen D.
dc.contributor.author
Alama Bermejo, Gema
dc.contributor.author
Maor Landaw, Keren
dc.contributor.author
Malik, Assaf
dc.contributor.author
Bartholomew, Jerri
dc.contributor.author
Lotan, Tamar
dc.date.available
2022-07-29T14:36:22Z
dc.date.issued
2021-04
dc.identifier.citation
Brekhman, Vera; Ofek Lalzar, Maya; Atkinson, Stephen D.; Alama Bermejo, Gema; Maor Landaw, Keren; et al.; Proteomic analysis of the parasitic Cnidarian Ceratonova shasta (Cnidaria: Myxozoa) reveals diverse roles of actin in motility and spore formation; Frontiers Media; Frontiers In Marine Science; 8; 4-2021; 1-8
dc.identifier.issn
2296-7745
dc.identifier.uri
http://hdl.handle.net/11336/163531
dc.description.abstract
Myxozoans are widely distributed aquatic obligate endoparasites that were recently recognized as belonging within the phylum Cnidaria. They have complex life cycles with waterborne transmission stages: resistant, infectious spores that are unique to myxozoans. However, little is known about the processes that give rise to these transmission stages. To understand the molecular underpinnings of spore formation, we conducted proteomics on Ceratonova shasta, a highly pathogenic myxozoan that causes severe mortalities in wild and hatchery-reared salmonid fishes. We compared proteomic profiles between developmental stages from inside the fish host, and the mature myxospore, which is released into the water where it drifts passively, ready to infect the next host. We found that C. shasta contains 2,123 proteins; representing the first proteomic catalog of a myxozoan myxospore. Analysis of proteins differentially expressed between developing and mature spore stages uncovered processes that are active during spore formation. Our data highlight dynamic changes in the actin cytoskeleton, which provides myxozoan developmental stages with mobility through lamellipodia and filopodia, whereas in the mature myxospore the actin network supports F-actin stabilization that reinforces the transmission stage. These findings provide molecular insight into the myxozoan life cycle stages and, particularly, into the process of sporogenesis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers Media
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
ACTIN
dc.subject
CNIDARIA
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CYTOSKELETON
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MYXOZOA
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PARASITE
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SPOROGENESIS
dc.subject.classification
Biología Celular, Microbiología
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Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Proteomic analysis of the parasitic Cnidarian Ceratonova shasta (Cnidaria: Myxozoa) reveals diverse roles of actin in motility and spore formation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-04-26T17:24:41Z
dc.journal.volume
8
dc.journal.pagination
1-8
dc.journal.pais
Suiza
dc.journal.ciudad
Lausana
dc.description.fil
Fil: Brekhman, Vera. University Of Haifa; Israel
dc.description.fil
Fil: Ofek Lalzar, Maya. University Of Haifa; Israel
dc.description.fil
Fil: Atkinson, Stephen D.. State University of Oregon; Estados Unidos
dc.description.fil
Fil: Alama Bermejo, Gema. Universidad Nacional del Comahue. Centro de Investigación Aplicada y Transferencia Tecnológica en Recursos Marinos "Almirante Storni". - Provincia de Río Negro. Ministerio de Agricultura, Ganadería y Pesca. Centro de Investigación Aplicada y Transferencia Tecnológica en Recursos Marinos "Almirante Storni". Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Centro Nacional Patagónico. Centro de Investigación Aplicada y Transferencia Tecnológica en Recursos Marinos "Almirante Storni"; Argentina. State University of Oregon; Estados Unidos. Institute of Parasitology. Biology Centre of the Czech Academy of Sciences; República Checa
dc.description.fil
Fil: Maor Landaw, Keren. University Of Haifa; Israel
dc.description.fil
Fil: Malik, Assaf. University Of Haifa; Israel
dc.description.fil
Fil: Bartholomew, Jerri. State University of Oregon; Estados Unidos
dc.description.fil
Fil: Lotan, Tamar. University Of Haifa; Israel
dc.journal.title
Frontiers In Marine Science
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fmars.2021.632700/full
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fmars.2021.632700
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