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dc.contributor.author
Hein, Gustavo Juan
dc.contributor.author
Baker, Chris
dc.contributor.author
Hsieh, Joanne
dc.contributor.author
Farr, Sara
dc.contributor.author
Khosrow, Adeli
dc.date.available
2017-05-11T20:23:19Z
dc.date.issued
2013-06
dc.identifier.citation
Hein, Gustavo Juan; Baker, Chris; Hsieh, Joanne; Farr, Sara; Khosrow, Adeli; GLP-1 and GLP-2 as Ying and Yang of Intestinal Lipoprotein Production: Evidence for predominance of GLP-2-stimulated postprandial lipemia in normal and insulin Resistant States; American Diabetes Association; Diabetes; 62; 2; 6-2013; 373-381
dc.identifier.issn
0012-1797
dc.identifier.uri
http://hdl.handle.net/11336/16339
dc.description.abstract
The glucagon-like peptides (GLP-1 and GLP-2) are processed from the proglucagon polypeptide and secreted in equimolar amounts but have opposite effects on chylomicron (CM) production, with GLP-1 significantly reducing and GLP-2 increasing postprandial chylomicronemia. In the current study, we evaluated the apparent paradoxical roles of GLP-1 and GLP-2 under physiological conditions in the Syrian golden hamster, a model with close similarity to humans in terms of lipoprotein metabolism. A short (30-min) intravenous infusion of GLP-2 resulted in a marked increase in postprandial apolipoprotein B48 (apoB48) and triglyceride (TG) levels in the TG-rich lipoprotein (TRL) fraction, whereas GLP-1 infusion decreased lipid absorption and levels of TRL-TG and apoB48. GLP-1 and GLP-2 coinfusion resulted in net increased lipid absorption and an increase in TRL-TG and apoB48. However, prolonged (120-min) coinfusion of GLP-1 and GLP-2 decreased postprandial lipemia. Blocking dipeptidyl peptidase-4 activity resulted in decreased postprandial lipemia. Interestingly, fructose-fed, insulin-resistant hamsters showed a more pronounced response, including possible hypersensitivity to GLP-2 or reduced sensitivity to GLP-1. In conclusion, under normal physiological conditions, the actions of GLP-2 predominate; however, when GLP-1 activity is sustained, the hypolipidemic action of GLP-1 predominates. Pharmacological inhibition of GLP-1 degradation tips the balance toward an inhibitory effect on intestinal production of atherogenic CM particles.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Diabetes Association
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Apolipoprotein B
dc.subject
Chylomicrons
dc.subject
Glucagon-Like Peptide
dc.subject
Dipeptidyl Peptidase-4
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
GLP-1 and GLP-2 as Ying and Yang of Intestinal Lipoprotein Production: Evidence for predominance of GLP-2-stimulated postprandial lipemia in normal and insulin Resistant States
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-04-17T19:25:35Z
dc.journal.volume
62
dc.journal.number
2
dc.journal.pagination
373-381
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Indianapolis
dc.description.fil
Fil: Hein, Gustavo Juan. University Of Toronto. Hospital For Sick Children; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Cs.veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina
dc.description.fil
Fil: Baker, Chris. University Of Toronto. Hospital For Sick Children; Canadá
dc.description.fil
Fil: Hsieh, Joanne. University Of Toronto. Hospital For Sick Children; Canadá
dc.description.fil
Fil: Farr, Sara. University Of Toronto. Hospital For Sick Children; Canadá
dc.description.fil
Fil: Khosrow, Adeli. University Of Toronto. Hospital For Sick Children; Canadá
dc.journal.title
Diabetes
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://diabetes.diabetesjournals.org/content/early/2012/09/19/db12-0202.abstract
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2337/db12-0202


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