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dc.contributor.author
Navarro, Ana
dc.contributor.author
Gomez, Carmen
dc.contributor.author
López Cepero, José M.
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dc.contributor.author
Boveris, Alberto Antonio
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dc.date.available
2022-07-27T16:11:16Z
dc.date.issued
2004-12
dc.identifier.citation
Navarro, Ana; Gomez, Carmen; López Cepero, José M.; Boveris, Alberto Antonio; Beneficial effects of moderate exercise on mice aging: Survival, behavior, oxidative stress, and mitochondrial electron transfer; American Physiological Society; American Journal of Physiology: Regulatory, Integrative and Comparative Physiology; 286; 3 55-3; 12-2004
dc.identifier.issn
0363-6119
dc.identifier.uri
http://hdl.handle.net/11336/163289
dc.description.abstract
Moderate exercise in a treadmill (10, 15, and 20 cm/s, for 5 min each, weekly) from 28 to 78 wk of age extended male and female mice life span by 19 and 9% accompanied by 36 and 13% and 13 and 9% increased performance in behavioral assays (tightrope and T-maze tests) at 52 wk of age. Moderate exercise significantly decreased the aging-associated development of oxidative stress by preventing 1) the increase in protein carbonyls and thiobarbituric acid-reactive substances contents of submitochondrial membranes; 2) the decrease in antioxidant enzyme activities (Mn- and Cu,Zn- superoxide dismutase and catalase); and 3) the decrease in mitochondrial NADH-cytochrome-c reductase and cytochrome oxidase activities observed at 52 wk of mice age in brain, heart, liver, and kidney. These effects were no longer significant at 78 wk of age in mice. Moderate exercise, started at young age in mice, increased life span, decreased oxidative stress, and prevented the decline of cytochrome oxidase activity and behavioral performance at middle age but not at old age.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Physiological Society
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CYTOCHROME OXIDASE
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Beneficial effects of moderate exercise on mice aging: Survival, behavior, oxidative stress, and mitochondrial electron transfer
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-07-15T15:23:53Z
dc.journal.volume
286
dc.journal.number
3 55-3
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Navarro, Ana. Universidad de Cádiz; España
dc.description.fil
Fil: Gomez, Carmen. Universidad de Cádiz; España
dc.description.fil
Fil: López Cepero, José M.. Universidad de Cádiz; España
dc.description.fil
Fil: Boveris, Alberto Antonio. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.journal.title
American Journal of Physiology: Regulatory, Integrative and Comparative Physiology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.physiology.org/doi/full/10.1152/ajpregu.00208.2003?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1152/ajpregu.00208.2003
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