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dc.contributor.author
Sacca, Paula Alejandra
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dc.contributor.author
Calvo, Juan Carlos
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dc.date.available
2022-07-26T17:35:36Z
dc.date.issued
2022-04
dc.identifier.citation
Sacca, Paula Alejandra; Calvo, Juan Carlos; Periprostatic adipose tissue microenvironment: metabolic and hormonal pathways during prostate cancer progression; Frontiers Media; Frontiers in Endocrinology; 13; 13; 4-2022; 1-6
dc.identifier.issn
1664-2392
dc.identifier.uri
http://hdl.handle.net/11336/163190
dc.description.abstract
The periprostatic adipose tissue (PPAT) is a site of invasion of prostate cancer (PCa) and is part of the microenvironment. It was shown that PPAT secretes factors and fatty acids (FAs) that alter the microenvironment of the PCa. The PPAT secretome of patients with PCa-T3 stage (PPAT-T3) has a metabolic profile enriched in several pathways related to energy production, indicating a greater energy requirement by the tumor, when compared to that of patients in the PCa-T2 stage (PPAT-T2). PPAT-T3 also shows enrichment in pathways related to hormone response, polyamine synthesis, and control of protein synthesis, through amino acid, RNA, and nucleotide metabolism. PPAT-T2 and PPAT-BPH secretomes have less complex metabolic profile, both related with energy balance, while PPAT-BPH has hormone response through insulin pathway. Undoubtedly, a deeper characterization of the human PPAT will lead to a better understanding of the disease and possibly allow new stratification factors and the design of a specific therapy that targets crucial components of the tumor microenvironment as another way to treat or control the disease.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers Media
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dc.relation
https://ri.conicet.gov.ar/handle/11336/129328
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ADIPOSE TISSUE
dc.subject
BENIGN PROSTATIC HYPERPLASIA
dc.subject
METABOLISM
dc.subject
MICROENVIRONMENT
dc.subject
PERIPROSTATIC ADIPOSE TISSUE
dc.subject
PROSTATE CANCER
dc.subject
PROTEOMICS
dc.subject
SECRETOME
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Periprostatic adipose tissue microenvironment: metabolic and hormonal pathways during prostate cancer progression
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-07-04T20:17:32Z
dc.journal.volume
13
dc.journal.number
13
dc.journal.pagination
1-6
dc.journal.pais
Suiza
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dc.journal.ciudad
Lausanne
dc.description.fil
Fil: Sacca, Paula Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Calvo, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
dc.journal.title
Frontiers in Endocrinology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fendo.2022.863027/full
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fendo.2022.863027
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