Artículo
HDL-associated enzymes and proteins in hemodialysis patients
Cacciagiú, Leonardo D.; González, Ana I.; Gomez Rosso, Leonardo Adrián
; Meroño, Tomás
; De Marziani, Guillermo; Elbert, Alicia; Berg, Gabriela Alicia
; Brites, Fernando Daniel
; Schreier, Laura Ester
Fecha de publicación:
02/2012
Editorial:
Elsevier
Revista:
Clinical Biochemistry
ISSN:
0009-9120
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
OBJECTIVES: To evaluate HDL-associated proteins and enzymes and their relation with lipoprotein profile and inflammatory markers in chronic renal patients on hemodialysis. DESIGN AND METHODS: We studied 53 patients under hemodialysis and 32 healthy subjects as controls. We compared plasma lipids, Apoprotein-AI and hs-CRP, as a marker of chronic inflammation. We evaluated proteins and enzymes associated to HDL, involved in several points of lipoprotein metabolism: CETP, paraoxonase and LpPLA2 activities. Hepatic lipase was measured in postheparin plasma. RESULTS: Patients showed higher triglycerides and lower LDL-, HDL- and total-cholesterol than controls (p<0.05). Also, in comparison with controls, Apoprotein-AI, paraoxonase and hepatic lipase were lower, while CETP was higher (p<0.03). LpPLA2 did not show changes between groups. CONCLUSION: Beyond plasma lipid-lipoprotein profile, other factors could contribute to induce a pro-oxidative and pro-inflammatory status. The protective role of HDL does not only depend on its concentration, but also on its functionality.
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Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Cacciagiú, Leonardo D.; González, Ana I.; Gomez Rosso, Leonardo Adrián; Meroño, Tomás; De Marziani, Guillermo; et al.; HDL-associated enzymes and proteins in hemodialysis patients; Elsevier; Clinical Biochemistry; 45; 3; 2-2012; 243-248
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