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dc.contributor.author
Amer, Mariano
dc.contributor.author
Elverdin, Juan Carlos
dc.contributor.author
Fernández Solari, Jose Javier
dc.contributor.author
Medina, Vanina Araceli
dc.contributor.author
Chiarenza, Ana P.
dc.contributor.author
Vacas, María I.
dc.date.available
2017-05-11T16:00:00Z
dc.date.issued
2011-05
dc.identifier.citation
Amer, Mariano; Elverdin, Juan Carlos; Fernández Solari, Jose Javier; Medina, Vanina Araceli; Chiarenza, Ana P.; et al.; Reduced methacholine-induced submandibular salivary secretion in rats with experimental periodontitis; Elsevier; Archives of Oral Biology; 56; 5; 5-2011; 421-427
dc.identifier.issn
0003-9969
dc.identifier.uri
http://hdl.handle.net/11336/16305
dc.description.abstract
OBJECTIVE: Saliva is the first barrier to the entry of bacteria and viruses into the body and is considered a necessary instrument in oral health. Intraperitoneal injection of lipopolysaccharide endotoxins results in submandibular gland (SMG) hyposalivation. The objective of present studies was to assess if periodontitis, a chronic inflammatory disease caused by oral bacteria, alters cholinergic-induced SMG salivary secretion. DESIGN: An experimental periodontitis model (EP) (cotton thread ligature around the neck of the first lower molars) was used. Male Wistar rats (300-380g) were randomly divided into 3 groups: control, 7 days-bilateral EP and 7 days-unilateral EP (to study if there were different effects at the ipsilateral and contralateral side). The following determinations were performed in SMG: (1) dose-response curves to the cholinergic agonist methacholine, (2) prostaglandin E (PGE) content, (3) inducible nitric oxide synthase (iNOS) activity and (4) histology of gland sections. RESULTS: The molars with EP, no matter the group, exhibited significant and similar bone loss (p<0.001). Bilateral EP reduced methacholine-induced salivary secretion (p<0.05, dose 1μg/kg; p<0.001, dose 3-30μg/kg), increased PGE content (p<0.01), stimulated iNOS activity (p<0.05). Ipsilateral glands of unilateral EP animals presented lower methacholine-induced salivary secretion (p<0.05, dose 3μg/kg; p<0.001, dose 10-30μg/kg), and higher PGE content than contralaterals (p<0.001). In turn, at 3 and 10μg/kg of methacholine, contralateral glands showed significantly lower secretion than control animals (p<0.001). Histological studies of glands revealed partial loss of secretor granular material and periductal oedema in the bilateral and unilateral EP groups as compared to controls. CONCLUSIONS: As far as we know, the present results demonstrate for the first time that EP reduces methacholine-induced SMG salivary secretion.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Periodontal Diseases
dc.subject
Submandibular Gland
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Salivary Secretion
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Inos
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Pge
dc.subject.classification
Fisiología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Reduced methacholine-induced submandibular salivary secretion in rats with experimental periodontitis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-05-10T19:58:53Z
dc.journal.volume
56
dc.journal.number
5
dc.journal.pagination
421-427
dc.journal.pais
Países Bajos
dc.journal.ciudad
Ámsterdam
dc.description.fil
Fil: Amer, Mariano. Universidad de Buenos Aires. Facultad de Odontología; Argentina
dc.description.fil
Fil: Elverdin, Juan Carlos. Universidad de Buenos Aires. Facultad de Odontología; Argentina
dc.description.fil
Fil: Fernández Solari, Jose Javier. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
dc.description.fil
Fil: Medina, Vanina Araceli. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Chiarenza, Ana P.. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Bioquímica General y Bucal; Argentina
dc.description.fil
Fil: Vacas, María I.. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Bioquímica General y Bucal; Argentina
dc.journal.title
Archives of Oral Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.archoralbio.2010.11.004
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0003996910003390
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