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dc.contributor.author
Virmani, T.
dc.contributor.author
Urbano Suarez, Francisco Jose
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Bisagno, Veronica
dc.contributor.author
Garcia Rill, Edgar
dc.date.available
2022-07-25T10:37:46Z
dc.date.issued
2019-09
dc.identifier.citation
Virmani, T.; Urbano Suarez, Francisco Jose; Bisagno, Veronica; Garcia Rill, Edgar; The pedunculopontine nucleus: From posture and locomotion to neuroepigenetics; AIMS Press; AIMS Neuroscience; 6; 4; 9-2019; 219-230
dc.identifier.issn
2373-7972
dc.identifier.uri
http://hdl.handle.net/11336/162966
dc.description.abstract
In this review, we discuss first an example of one of the symptoms of PD, freezing of gait (FOG), then we will turn to the use of deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) to treat PD, and the original studies that led to identification of the PPN as one source of locomotor control and why stimulation frequency is critical, and then describe the intrinsic properties of PPN neurons that require beta/gamma stimulation in order to fully activate all types of PPN neurons. Finally, we will describe recent findings on the proteomic and molecular consequences of gamma band activity in PPN neurons, with emphasis on the potential neuroepigenetic sequelae. These considerations will provide essential information for the appropriate refining and testing of PPN DBS as a potential therapy for PD, as well as alternative options.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
AIMS Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AROUSAL
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DEEP BRAIN STIMULATION
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F-ACTIN
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HISTONE DEACETYLASE
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N- AND P/Q-TYPE CALCIUM CHANNELS
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REM SLEEP
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TRICHOSTATIN A
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WAKING
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Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
The pedunculopontine nucleus: From posture and locomotion to neuroepigenetics
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-06-21T19:24:34Z
dc.journal.volume
6
dc.journal.number
4
dc.journal.pagination
219-230
dc.journal.pais
Estados Unidos
dc.journal.ciudad
New York
dc.description.fil
Fil: Virmani, T.. University of Arkansas for Medical Sciences; Estados Unidos
dc.description.fil
Fil: Urbano Suarez, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina
dc.description.fil
Fil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina
dc.description.fil
Fil: Garcia Rill, Edgar. University of Arkansas for Medical Sciences; Estados Unidos
dc.journal.title
AIMS Neuroscience
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3934/Neuroscience.2019.4.219
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.aimspress.com/article/10.3934/Neuroscience.2019.4.219
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