Artículo
Reduced faecal shedding of Escherichia coli O157:H7 in cattle following systemic vaccination with γ-intimin C280 and EspB proteins
Vilte, Daniel A.; Larzabal, Mariano
; Garbaccio, Sergio; Gammella, Mariela; Rabinovitz, Bettina Carol
; Elizondo, Ana M.; Cantet, Rodolfo Juan Carlos
; Delgado, Fernando; Meikle, Virginia; Cataldi, Angel Adrian
; Mercado, Elsa C.
Fecha de publicación:
05/2011
Editorial:
Elsevier
Revista:
Vaccine
ISSN:
0264-410X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Enterohaemorrhagic Escherichia coli (EHEC) O157:H7 is the most prevalent EHEC serotype that has been recovered from patients with haemolytic uremic syndrome (HUS) worldwide. Vaccination of cattle, the main reservoir of EHEC O157:H7, could be a logical strategy to fight infection in humans. This study evaluated a vaccine based on the carboxyl-terminal fragment of 280 amino acids of -intimin (-intimin C280) and EspB, two key colonization factors of E. coli O157:H7. Intramuscular immunization elicited significantly high levels of serum IgG antibodies against both proteins. Antigen-specific IgA and IgG were also induced in saliva, but only the IgA response was significant. Following experimental challenge with E. coli O157:H7, a significant reduction in bacterial shedding was observed in vaccinated calves, compared to control group. These promising results suggest that systemic immunization of cattle with intimin and EspB could be a feasible strategy to reduce EHEC O157:H7 faecal shedding in cattle.
Palabras clave:
E.Coli O157:H7
,
Cattle
,
Vaccination
,
Intimin Espb
Archivos asociados
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Identificadores
Colecciones
Articulos(OCA PQUE. CENTENARIO)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA PQUE. CENTENARIO
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA PQUE. CENTENARIO
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Vilte, Daniel A.; Larzabal, Mariano; Garbaccio, Sergio; Gammella, Mariela; Rabinovitz, Bettina Carol; et al.; Reduced faecal shedding of Escherichia coli O157:H7 in cattle following systemic vaccination with γ-intimin C280 and EspB proteins; Elsevier; Vaccine; 29; 23; 5-2011; 3962-3968
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