Artículo
Drug resistance mutations in HIV pol sequences from Argentinean patients under antiretroviral treatment: subtype, gender and age issues
Jones, Leandro Roberto
; Moretti, Franco; Calvo, Andrea Yamila
; Dilernia, Dario Alberto
; Manrique, Julieta Marina
; Gómez Carrillo, Manuel
; Salomon, Horacio Eduardo
Fecha de publicación:
12/2011
Editorial:
Mary Ann Liebert Inc
Revista:
Aids Research And Human Retroviruses
ISSN:
0889-2229
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
We studied drug resistance mutations (DRMs) in 2623 pol sequences. Out of 94,828 amino acid substitutions that were detected, 8749 corresponded to nucleoside reverse transcriptase inhibitor (NRTI), 3765 to nonnucleoside reverse transcriptase inhibitor (NNRTI), and 7141 to protease inhibitor (PI) resistance-associated mutations. The most common DRMs were L10I, I54V, L90M, V82A, A71V, L10V, M46I, M184V, M41L, T215Y, D67N, L210W, K70R, N348I, V118I, K103N, Y181C, G190A, K101E, V108I, L100I, V90I, K101Q, and A98G. As expected, DRMs frequencies depended on viral genotype. The amounts of NRTI and PI resistance mutations among B and BF sequences from children were higher than among sequences from adults. The frequencies of PI and NRTI resistance mutations among B and BF sequences from adult men were higher than among sequences from women. Some of these observations can be explained in light of the available epidemiological information, but some cannot, indicating that further studies are needed to understand the antiretroviral resistance epidemics in Argentina.
Palabras clave:
Hiv/Aids
,
Drug Resistance
,
Molecular Epidemiology
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Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Jones, Leandro Roberto; Moretti, Franco; Calvo, Andrea Yamila; Dilernia, Dario Alberto; Manrique, Julieta Marina; et al.; Drug resistance mutations in HIV pol sequences from Argentinean patients under antiretroviral treatment: subtype, gender and age issues; Mary Ann Liebert Inc; Aids Research And Human Retroviruses; 28; 8; 12-2011; 949-955
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