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dc.contributor.author
Urbano Suarez, Francisco Jose  
dc.contributor.author
Bisagno, Veronica  
dc.contributor.other
Preedy, V. R.  
dc.date.available
2022-07-20T15:25:58Z  
dc.date.issued
2017  
dc.identifier.citation
Urbano Suarez, Francisco Jose; Bisagno, Veronica; Cocaine Enhances Gamma-Aminobutyric Acid Release From Reticular Thalamic Nucleus: Role of T-Type Calcium Channels; Academic Press; 2017; 511-518  
dc.identifier.isbn
978-0-12-803750-8  
dc.identifier.uri
http://hdl.handle.net/11336/162657  
dc.description.abstract
Thalamic reticular nucleus (TRN) neurons are extensivelymodulated by cocaines inhibition of catecholaminereuptake at both the somatic and synaptic levels. Systemic cocaine binge administration in miceenhanced gamma-aminobutyric acid (GABA) releaseat the thalamic level that was correlated to abnormallyhigh levels of low-frequency oscillations at corticalelectroencephalography. Cocaine mediated local anesthetic-like effects, reducingaction potential frequency during whole-cellpatch-clamp recordings in TRN neurons. Multiple cocaine binge administration increased proteinlevels of T-type CaV3.1 and glutamate decarboxylaseon TRN-VB synapses. Long-lasting cocaine effects on GABAergic neurotransmissionmight be mediated by homeostatic compensatorymechanisms at TRN.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Academic Press  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
COCAINE  
dc.subject
THALAMIC  
dc.subject
CALCIUM CHANNELS  
dc.subject
SNC  
dc.subject.classification
Farmacología y Farmacia  
dc.subject.classification
Medicina Básica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Cocaine Enhances Gamma-Aminobutyric Acid Release From Reticular Thalamic Nucleus: Role of T-Type Calcium Channels  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.type
info:eu-repo/semantics/bookPart  
dc.type
info:ar-repo/semantics/parte de libro  
dc.date.updated
2022-06-21T19:25:56Z  
dc.journal.pagination
511-518  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
New York  
dc.description.fil
Fil: Urbano Suarez, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina  
dc.description.fil
Fil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.elsevier.com/books/the-neuroscience-of-cocaine/preedy/978-0-12-803750-8  
dc.conicet.paginas
700  
dc.source.titulo
The Neuroscience of Cocaine: Mechanisms and treatments  

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