Mostrar el registro sencillo del ítem
dc.contributor.author
Höcht, Christian
dc.contributor.author
Opezzo, Javier A. W.
dc.contributor.author
Taira, Carlos Alberto
dc.date.available
2022-07-20T12:51:12Z
dc.date.issued
2007-12
dc.identifier.citation
Höcht, Christian; Opezzo, Javier A. W.; Taira, Carlos Alberto; Applicability of reverse microdialysis in pharmacological and toxicological studies; Elsevier; Journal Of Pharmacological And Toxicological Methods.; 55; 1; 12-2007; 3-15
dc.identifier.issn
1056-8719
dc.identifier.uri
http://hdl.handle.net/11336/162620
dc.description.abstract
A recent application of microdialysis is the introduction of a substance into the extracellular space via the microdialysis probe. The inclusion of a higher amount of a drug in the perfusate allows the drug to diffuse through the microdialysis membrane to the tissue. This technique, actually called as reverse microdialysis, not only allows the local administration of a substance but also permits the simultaneous sampling of the extracellular levels of endogenous compounds. Local effects of exogenous compounds have been studied in the central nervous system, hepatic tissue, dermis, heart and corpora luteae of experimental animals by means of reverse microdialysis. In central nervous studies, reverse microdialysis has been extensively used for the study of the effects on neurotransmission at different central nuclei of diverse pharmacological and toxicological agents, such as antidepressants, antipsychotics, antiparkinsonians, hallucinogens, drugs of abuse and experimental drugs. In the clinical setting, reverse microdialysis has been used for the study of local effects of drugs in the adipose tissue, skeletal muscle and dermis. The aim of this review is to describe the principles of the reverse microdialysis, to compare the technique with other available methods and finally to describe the applicability of reverse microdialysis in the study of drugs properties both in basic and clinical research.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
BASIC RESEARCH
dc.subject
CLINICAL APPLICATIONS
dc.subject
DELIVERY METHODS
dc.subject
NEUROTRANSMISSION
dc.subject
PHARMACOLOGICAL AND TOXICOLOGICAL AGENTS
dc.subject
REVERSE MICRODIALYSIS
dc.subject
SAMPLING METHODS
dc.title
Applicability of reverse microdialysis in pharmacological and toxicological studies
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-07-15T15:23:00Z
dc.journal.volume
55
dc.journal.number
1
dc.journal.pagination
3-15
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Höcht, Christian. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Opezzo, Javier A. W.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina
dc.description.fil
Fil: Taira, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina
dc.journal.title
Journal Of Pharmacological And Toxicological Methods.
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1056871906000220
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.vascn.2006.02.007
Archivos asociados