Mostrar el registro sencillo del ítem

dc.contributor.author
Höcht, Christian  
dc.contributor.author
Opezzo, Javier A. W.  
dc.contributor.author
Taira, Carlos Alberto  
dc.date.available
2022-07-20T12:51:12Z  
dc.date.issued
2007-12  
dc.identifier.citation
Höcht, Christian; Opezzo, Javier A. W.; Taira, Carlos Alberto; Applicability of reverse microdialysis in pharmacological and toxicological studies; Elsevier; Journal Of Pharmacological And Toxicological Methods.; 55; 1; 12-2007; 3-15  
dc.identifier.issn
1056-8719  
dc.identifier.uri
http://hdl.handle.net/11336/162620  
dc.description.abstract
A recent application of microdialysis is the introduction of a substance into the extracellular space via the microdialysis probe. The inclusion of a higher amount of a drug in the perfusate allows the drug to diffuse through the microdialysis membrane to the tissue. This technique, actually called as reverse microdialysis, not only allows the local administration of a substance but also permits the simultaneous sampling of the extracellular levels of endogenous compounds. Local effects of exogenous compounds have been studied in the central nervous system, hepatic tissue, dermis, heart and corpora luteae of experimental animals by means of reverse microdialysis. In central nervous studies, reverse microdialysis has been extensively used for the study of the effects on neurotransmission at different central nuclei of diverse pharmacological and toxicological agents, such as antidepressants, antipsychotics, antiparkinsonians, hallucinogens, drugs of abuse and experimental drugs. In the clinical setting, reverse microdialysis has been used for the study of local effects of drugs in the adipose tissue, skeletal muscle and dermis. The aim of this review is to describe the principles of the reverse microdialysis, to compare the technique with other available methods and finally to describe the applicability of reverse microdialysis in the study of drugs properties both in basic and clinical research.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
BASIC RESEARCH  
dc.subject
CLINICAL APPLICATIONS  
dc.subject
DELIVERY METHODS  
dc.subject
NEUROTRANSMISSION  
dc.subject
PHARMACOLOGICAL AND TOXICOLOGICAL AGENTS  
dc.subject
REVERSE MICRODIALYSIS  
dc.subject
SAMPLING METHODS  
dc.title
Applicability of reverse microdialysis in pharmacological and toxicological studies  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2022-07-15T15:23:00Z  
dc.journal.volume
55  
dc.journal.number
1  
dc.journal.pagination
3-15  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Höcht, Christian. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina  
dc.description.fil
Fil: Opezzo, Javier A. W.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina  
dc.description.fil
Fil: Taira, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina  
dc.journal.title
Journal Of Pharmacological And Toxicological Methods.  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1056871906000220  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.vascn.2006.02.007