Mostrar el registro sencillo del ítem

dc.contributor.author
Anselmino Dieterle, Luciano Emanuel  
dc.contributor.author
Malizia, Florencia  
dc.contributor.author
Menacho Márquez, Mauricio Ariel  
dc.date.available
2022-07-19T18:24:04Z  
dc.date.issued
2019-05  
dc.identifier.citation
Anselmino Dieterle, Luciano Emanuel; Malizia, Florencia; Menacho Márquez, Mauricio Ariel; Modern Strategies in Cancer Study: Drug Repositioning in Colorectal Cancer Treatment; Crimson Publisher; Novel Approaches in Cancer Study; 2; 4; 5-2019; 1-5  
dc.identifier.issn
2637-773X  
dc.identifier.uri
http://hdl.handle.net/11336/162564  
dc.description.abstract
Colorectal cancer is one of the most fatal cancers in the world because most of cases are diagnosed in advanced stages, when the development of resistance to chemotherapy is more frequent. To face this situation, new drugs and drug combinations would be necessary. Drug discovery is a very costly process; although efforts in drug discovery have been amplified in recent decades the success rate of approved FDA drugs continues being low. In response to this situation the repositioning of drugs proposes to delve into the genetic, epigenetic and metabolic differences to discover new targets and redirect drugs already approved to the treatment of other diseases and conditions. In this minireview we discuss the main avenues in which repositioning can occur and we cite some examples of repositioning drugs in colorectal cancer treatment that are being tested in clinical trials in the last years.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Crimson Publisher  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
COLORECTAL CANCER  
dc.subject
DRUG REPOSITIONING  
dc.subject
CLINICAL TRIALS  
dc.subject.classification
Salud Pública y Medioambiental  
dc.subject.classification
Ciencias de la Salud  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Modern Strategies in Cancer Study: Drug Repositioning in Colorectal Cancer Treatment  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2021-04-28T20:41:10Z  
dc.journal.volume
2  
dc.journal.number
4  
dc.journal.pagination
1-5  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Nueva York  
dc.description.fil
Fil: Anselmino Dieterle, Luciano Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina  
dc.description.fil
Fil: Malizia, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina  
dc.description.fil
Fil: Menacho Márquez, Mauricio Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina  
dc.journal.title
Novel Approaches in Cancer Study  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.31031/NACS.2019.02.000544  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://crimsonpublishers.com/nacs/fulltext/NACS.000544.php