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dc.contributor.author
Waxman Dova, Samanta
dc.contributor.author
de Lucas, José Julio
dc.contributor.author
Wiemeyer, Guillermo
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Torres Bianchini, Laura
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San Andrés, Manuel Ignacio
dc.contributor.author
Rodríguez, Casilda
dc.date.available
2022-07-13T18:00:22Z
dc.date.issued
2021-08
dc.identifier.citation
Waxman Dova, Samanta; de Lucas, José Julio; Wiemeyer, Guillermo; Torres Bianchini, Laura; San Andrés, Manuel Ignacio; et al.; Pharmacokinetic behaviour of enrofloxacin after single intramuscular dosage in american black vultures (Coragyps atratus); MDPI AG; Antibiotics; 10; 8; 8-2021; 1-7
dc.identifier.issn
2079-6382
dc.identifier.uri
http://hdl.handle.net/11336/162035
dc.description.abstract
The aim of the study was to investigate the intramuscular pharmacokinetics of enrofloxacin in black vultures (Coragyps atratus). The pharmacokinetics of a single intramuscular dose (10 mg/kg) of enrofloxacin was studied in six vultures. Plasma concentrations of enrofloxacin and its active metabolite, ciprofloxacin, were determined by high-performance liquid chromatography (HPLCuv). Pharmacokinetic parameters were estimated using non-compartmental and compartmental analysis. After intramuscular administration, enrofloxacin showed a rapid and complete absorption, reaching a Cmax value of 3.26 ± 0.23 μg/mL at 1.75 ± 0.53 h. A long terminal half-life of 19.58 h has been observed. Using previously published MIC values to perform a PK/PD analysis, cumulative fraction responses obtained after Monte Carlo simulation for AUC/MIC > 30, 50 and 125 were 72.93%, 72.34% and 30.86% for E. coli and 89.29%, 88.89% and 58.57% for Mycoplasma synoviae, respectively. Cumulative fraction responses obtained for Cmax/MIC index were 33.93% and 40.18% for E. coli and M. synoviae, respectively. The intramuscular administration of 10 mg/kg could be appropriate to treat infectious diseases caused by gram-positive bacteria with MIC value lower than 1 µg/mL; however, although enrofloxacin showed a slow elimination in black vultures, plasma concentrations were insufficient to reach the gram-negative stablished breakpoints.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
MDPI AG
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
BLACK VULTURES
dc.subject
ENROFLOXACIN
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MONTE CARLO SIMULATION
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PHARMACOKINETIC
dc.subject
PK/PD
dc.subject.classification
Ciencias Veterinarias
dc.subject.classification
Ciencias Veterinarias
dc.subject.classification
CIENCIAS AGRÍCOLAS
dc.title
Pharmacokinetic behaviour of enrofloxacin after single intramuscular dosage in american black vultures (Coragyps atratus)
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-06-21T18:33:10Z
dc.journal.volume
10
dc.journal.number
8
dc.journal.pagination
1-7
dc.journal.pais
Suiza
dc.journal.ciudad
Basilea
dc.description.fil
Fil: Waxman Dova, Samanta. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: de Lucas, José Julio. Universidad Complutense de Madrid. Facultad de Veterinaria; España
dc.description.fil
Fil: Wiemeyer, Guillermo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Torres Bianchini, Laura. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: San Andrés, Manuel Ignacio. Universidad Complutense de Madrid. Facultad de Veterinaria; España
dc.description.fil
Fil: Rodríguez, Casilda. Universidad Complutense de Madrid. Facultad de Veterinaria; España
dc.journal.title
Antibiotics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2079-6382/10/8/957
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/antibiotics10080957
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