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dc.contributor.author
Rodriguez Granillo, Gaston Alfredo  
dc.contributor.author
Reynoso, Exequiel  
dc.contributor.author
Capuñay, Carlos  
dc.contributor.author
Antoniades, Charalambos  
dc.contributor.author
Shaw, Leslee J.  
dc.contributor.author
Carrascosa, Patricia  
dc.date.available
2022-07-08T16:48:24Z  
dc.date.issued
2019-01  
dc.identifier.citation
Rodriguez Granillo, Gaston Alfredo; Reynoso, Exequiel; Capuñay, Carlos; Antoniades, Charalambos; Shaw, Leslee J.; et al.; Prognostic Value of Vascular Calcifications and Regional Fat Depots Derived From Conventional Chest Computed Tomography; Lippincott Williams; Journal of Thoracic Imaging; 34; 1; 1-2019; 33-40  
dc.identifier.issn
0883-5993  
dc.identifier.uri
http://hdl.handle.net/11336/161736  
dc.description.abstract
Purpose: The prognostic value of vascular calcifications as well as of regional fat depots has been reported separately, in population-based studies, and using gated-computed tomography (CT) examinations. We, therefore, explored the interplay and prognostic value of vascular calcifications and adipose tissue depots assessed during conventional nongated chest CT. Materials and Methods: We enrolled a consecutive series of 1250 patients aged between 35 and 74 years who underwent clinically indicated chest CT scans. We measured the extent of coronary artery calcification (CAC) using the segment-involvement score (CACSIS), and aortic and valve calcification. Pericardial fat volume (PFV), hepatic fat, and abdominal subcutaneous adipose tissue were also calculated. Patients were followed-up for all-cause mortality. Results: A total of 577 (46%) patients had presence of CAC in the coronary tree. Over a mean follow-up of 3.7 years, 51 (4%) deaths occurred, 23 (4.1%) in male patients and 28 (4.1%) in female patients. Patients with higher PFV were older (P<0.0001), more frequently male (P<0.0001), had higher abdominal subcutaneous adipose tissue (P<0.0001), hepatic fat (P<0.0001), as well as a larger extent of CAC (P<0.0001), aortic calcium (P<0.0001), and valve calcium (P<0.0001). From a multivariable Cox regression model, age (hazard ratio [HR], 1.07; 95% confidence interval [CI], 1.03-1.11), P=0.001, PFV upper tertile (HR, 4.07; 95% CI, 2.09-7.92), P<0.0001, and CACSIS>5 (HR, 2.19; 95% CI, 1.14-4.23; P<0.0001) were independent predictors of all-cause death. Conclusions: In this relatively large patient cohort undergoing clinically indicated conventional chest CT scans, PFV and coronary calcification were high-risk markers associated with worsening survival.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Lippincott Williams  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
CALCIUM  
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CORONARY  
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OBESITY  
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PERICARDIAL FAT  
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PROGNOSIS  
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TOMOGRAPHY  
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Sistemas Cardíaco y Cardiovascular  
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Medicina Clínica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Prognostic Value of Vascular Calcifications and Regional Fat Depots Derived From Conventional Chest Computed Tomography  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2022-06-21T19:29:40Z  
dc.journal.volume
34  
dc.journal.number
1  
dc.journal.pagination
33-40  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Philadelphia  
dc.description.fil
Fil: Rodriguez Granillo, Gaston Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina  
dc.description.fil
Fil: Reynoso, Exequiel. No especifíca;  
dc.description.fil
Fil: Capuñay, Carlos. No especifíca;  
dc.description.fil
Fil: Antoniades, Charalambos. University of Oxford; Reino Unido  
dc.description.fil
Fil: Shaw, Leslee J.. University of Georgia; Estados Unidos  
dc.description.fil
Fil: Carrascosa, Patricia. No especifíca;  
dc.journal.title
Journal of Thoracic Imaging  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://journals.lww.com/00005382-201901000-00007  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1097/RTI.0000000000000370