Artículo
Extracellular ATP and Imbalance of CD4+ T Cell Compartment in Pediatric COVID-19
Russo, Constanza Andrea; Raiden, Silvina Claudia
; Algieri, Silvia; De Carli, Norberto; Davenport, Carolina; Sarli, Mariam; Bruera, María José; Seery, Vanesa
; Sananez, Inés
; Simaz, Nancy; Bayle, Carola; Nivela, Valeria; Ferrero, Fernando; Geffner, Jorge Raúl
; Arruvito, Maria Lourdes
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Fecha de publicación:
05/2022
Editorial:
Frontiers Media
Revista:
Frontiers in Cellular and Infection Microbiology
ISSN:
2235-2988
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Severe COVID-19 in children is rare, but the reasons underlying are unclear. Profoundalterations in T cell responses have been well characterized in the course of adult severeCOVID-19, but little is known about the T cell function in children with COVID-19. Here, wemade three major observations in a cohort of symptomatic children with acute COVID-19:1) a reduced frequency of circulating FoxP3+ regulatory T cells, 2) the prevalence of aTH17 polarizing microenvironment characterized by high plasma levels of IL-6, IL-23, andIL17A, and an increased frequency of CD4+ T cells expressing ROR-gt, the masterregulator of TH17 development, and 3) high plasma levels of ATP together with anincreased expression of the P2X7 receptor. Moreover, that plasma levels of ATP displayedan inverse correlation with the frequency of regulatory T cells but a positive correlation withthe frequency of CD4+ T cells positive for the expression of ROR-gt. Collectively, our dataindicate an imbalance in CD4+ T cell profiles during pediatric COVID-19 that might favorthe course of inflammatory processes. This finding also suggests a possible role for theextracellular ATP in the acquisition of an inflammatory signature by the T cell compartmentoffering a novel understanding of the involved mechanisms.
Palabras clave:
COVID-19
,
CHILDREN
,
EXTRACELLULAR ATP
,
T REGS
,
TH17 CELLS
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Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Russo, Constanza Andrea; Raiden, Silvina Claudia; Algieri, Silvia; De Carli, Norberto; Davenport, Carolina; et al.; Extracellular ATP and Imbalance of CD4+ T Cell Compartment in Pediatric COVID-19; Frontiers Media; Frontiers in Cellular and Infection Microbiology; 12; 893044; 5-2022; 1-10
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