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dc.contributor.author
Magnani, Natalia Daniela  
dc.contributor.author
Dada, Laura Andrea  
dc.contributor.author
Sznajder, Jacob I.  
dc.date.available
2022-07-04T15:36:29Z  
dc.date.issued
2018-08  
dc.identifier.citation
Magnani, Natalia Daniela; Dada, Laura Andrea; Sznajder, Jacob I.; Ubiquitin-proteasome signaling in lung injury; Elsevier Science Inc.; Translational Research; 198; 8-2018; 29-39  
dc.identifier.issn
1931-5244  
dc.identifier.uri
http://hdl.handle.net/11336/161156  
dc.description.abstract
Cell homeostasis requires precise coordination of cellular proteins function. Ubiquitination is a post-translational modification that modulates protein half-life and function and is tightly regulated by ubiquitin E3 ligases and deubiquitinating enzymes. Lung injury can progress to acute respiratory distress syndrome that is characterized by an inflammatory response and disruption of the alveolocapillary barrier resulting in alveolar edema accumulation and hypoxemia. Ubiquitination plays an important role in the pathobiology of acute lung injury as it regulates the proteins modulating the alveolocapillary barrier and the inflammatory response. Better understanding of the signaling pathways regulated by ubiquitination may lead to novel therapeutic approaches by targeting specific elements of the ubiquitination pathways.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Science Inc.  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Ubiquitin  
dc.subject
Lung injury  
dc.subject
Proteosome signaling  
dc.subject.classification
Biología Celular, Microbiología  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Ubiquitin-proteasome signaling in lung injury  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2022-06-21T19:30:04Z  
dc.journal.volume
198  
dc.journal.pagination
29-39  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Magnani, Natalia Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Programa de Radicales Libres; Argentina. Northwestern University; Estados Unidos  
dc.description.fil
Fil: Dada, Laura Andrea. Northwestern University; Estados Unidos  
dc.description.fil
Fil: Sznajder, Jacob I.. Northwestern University; Estados Unidos  
dc.journal.title
Translational Research  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1931524418300574  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.trsl.2018.04.003