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dc.contributor.author
Dini, Cecilia
dc.contributor.author
Islan, German Abel
dc.contributor.author
Castro, Guillermo Raul
dc.date.available
2017-05-08T21:31:08Z
dc.date.issued
2014-11
dc.identifier.citation
Dini, Cecilia; Islan, German Abel; Castro, Guillermo Raul; Characterization and Stability Analysis of Biopolymeric Matrices Designed for Phage-Controlled Release; Springer; Applied Biochemistry And Biotechnology; 174; 6; 11-2014; 2031-2047
dc.identifier.issn
0273-2289
dc.identifier.uri
http://hdl.handle.net/11336/16110
dc.description.abstract
Alginate and low methoxylated pectin gel matrices emulsified with oleic acid were studied for phage oral delivery. Matrix structural analysis revealed that emulsified pectin (EP) gel microbeads were harder and more cohesive than those of emulsified alginate (EA). EP showed high swelling capacity and slower matrix degradation in aqueous media, suggesting that oleic acid is mainly located on the surface of EP microbeads. EA and EP matrices having p-nitrophenyl palmitate (C-16 ester) as tracer dissolved into oleic acid and in the presence of lipase confirmed this hypothesis which is consistent with EP better phage protective capability. Surface analysis of gel microbeads by scanning electron microscopy revealed strong differences between EP and EA gel microbeads. Phage release kinetics was tested using semi-empirical mathematical models. Experimental curve best fitted the Korsmeyer–Peppas model, predicting transport mechanisms according to the high swelling and degradation of EP. The proposed encapsulation model represents an innovative technology for phage therapy, which can be extrapolated to other therapeutic purposes, using a simple environmentally friendly synthesis procedure and cheap food-grade raw materials.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Modeling
dc.subject
Pectin
dc.subject
Alginate
dc.subject
Biopolymers
dc.subject
Microencapsulation
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Phage Therapy
dc.subject.classification
Bioproductos, Biomateriales, Bioplásticos, Biocombustibles, Bioderivados, etc.
dc.subject.classification
Biotecnología Industrial
dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
dc.title
Characterization and Stability Analysis of Biopolymeric Matrices Designed for Phage-Controlled Release
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-05-08T15:31:02Z
dc.identifier.eissn
1559-0291
dc.journal.volume
174
dc.journal.number
6
dc.journal.pagination
2031-2047
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Dini, Cecilia. Provincia de Buenos Aires. Gobernación. Comision de Invest.científicas. Centro de Investigación y Desarrollo En Criotecnología de Alimentos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigación y Desarrollo En Criotecnología de Alimentos. Universidad Nacional de la Plata. Facultad de Cs.exactas. Centro de Investigación y Desarrollo En Criotecnología de Alimentos; Argentina
dc.description.fil
Fil: Islan, German Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigación y Desarrollo En Fermentaciones Industriales. Universidad Nacional de la Plata. Facultad de Cs.exactas. Centro de Investigación y Desarrollo En Fermentaciones Industriales; Argentina
dc.description.fil
Fil: Castro, Guillermo Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigación y Desarrollo En Fermentaciones Industriales. Universidad Nacional de la Plata. Facultad de Cs.exactas. Centro de Investigación y Desarrollo En Fermentaciones Industriales; Argentina
dc.journal.title
Applied Biochemistry And Biotechnology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/ 10.1007/s12010-014-1152-3
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs12010-014-1152-3
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