Artículo
Behavioral differences on memory retrieval between two variants of step-through inhibitory avoidance task in mice
Fecha de publicación:
10/2008
Editorial:
Elsevier Ireland
Revista:
Neuroscience Letters
ISSN:
0304-3940
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
For several decades, one-trial inhibitory avoidance (IA) tasks have been used in the study of memory processing. In the present work, the effects of diazepam (DZP) (0.5mg/kg) and picrotoxin (PIC) (0.3mg/kg) on memory retrieval were assessed using two variants of a step-through IA situation in CF-1 mice. In the first variant, animals get into a dark compartment from an open illuminated platform (platform), whereas in the other, from an enclosed illuminated one (box). PIC impaired retention performance in the "platform-type" IA, but not in the "box-type". DZP enhanced retention performance in both types of IA task. These results evidence critical differences between the two step-through inhibitory avoidance tasks used, that might be relevant not only for retention performance during memory retrieval, but also for the theoretical interpretations and conclusions obtained from behavioral results.
Palabras clave:
DIAZEPAM
,
INHIBITORY AVOIDANCE
,
MEMORY RETRIEVAL
,
MICE
,
PICROTOXIN
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Identificadores
Colecciones
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Blake, Mariano Guillermo; Boccia, Mariano Martín; Baratti, Carlos Maria; Behavioral differences on memory retrieval between two variants of step-through inhibitory avoidance task in mice; Elsevier Ireland; Neuroscience Letters; 444; 1; 10-2008; 102-105
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