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dc.contributor.author
Perez Lloret, Santiago
dc.contributor.author
Quarracino, Cecilia
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Otero-losada, Matilde Estela
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Rascol, Olivier
dc.date.available
2022-06-28T13:17:30Z
dc.date.issued
2019-02
dc.identifier.citation
Perez Lloret, Santiago; Quarracino, Cecilia; Otero-losada, Matilde Estela; Rascol, Olivier; Droxidopa for the treatment of neurogenic orthostatic hypotension in neurodegenerative diseases; Taylor & Francis; Expert Opinion on Pharmacotherapy; 20; 6; 2-2019; 635-645
dc.identifier.issn
1465-6566
dc.identifier.uri
http://hdl.handle.net/11336/160602
dc.description.abstract
Introduction: L-threo-3,4-dihydroxyphenylserine (droxidopa), a pro-drug metabolized to norepinephrine in nerve endings and other tissues, has been commercially available in Japan since 1989 for treating orthostatic hypotension symptoms in Parkinson’s disease (PD) patients with a Hoehn & Yahr stage III rating, as well as patients with Multiple System Atrophy (MSA), familial amyloid polyneuropathy, and hemodialysis. Recently, the FDA has approved its use in symptomatic neurogenic orthostatic hypotension (NOH). Areas covered: The authors review the effects of droxidopa in NOH with a focus on the neurodegenerative diseases PD, MSA, and pure autonomic failure (PAF). Expert opinion: A few small and short placebo-controlled clinical trials in NOH showed significant reductions in the manometric drop in blood pressure (BP) after posture changes or meals. Larger Phase III studies showed conflicting results, with two out of four trials meeting their primary outcome and thus suggesting a positive yet short-lasting effect of the drug on OH Questionnaire composite score, light-headedness/dizziness score, and standing BP during the first two treatment-weeks. Results appear essentially similar in PD, MSA, and PAF. The FDA granted droxidopa approval in the frame of an ‘accelerated approval program’ provided further studies are conducted to assess its long-term effects on OH symptoms.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Taylor & Francis
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
DROXIDOPA
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MULTIPLE SYSTEM ATROPHY
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NEUROGENIC ORTHOSTATIC HYPOTENSION
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PARKINSON’S DISEASE
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PURE AUTONOMIC FAILURE
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SYNUCLEINOPATHIES
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Farmacología y Farmacia
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Droxidopa for the treatment of neurogenic orthostatic hypotension in neurodegenerative diseases
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-06-21T19:30:06Z
dc.journal.volume
20
dc.journal.number
6
dc.journal.pagination
635-645
dc.journal.pais
Reino Unido
dc.journal.ciudad
London
dc.description.fil
Fil: Perez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
dc.description.fil
Fil: Quarracino, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
dc.description.fil
Fil: Otero-losada, Matilde Estela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
dc.description.fil
Fil: Rascol, Olivier. Université Paul Sabatier; Francia
dc.journal.title
Expert Opinion on Pharmacotherapy
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1080/14656566.2019.1574746
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/14656566.2019.1574746
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