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dc.contributor.author
Martín Rodríguez, Francisco
dc.contributor.author
López Izquierdo, Raúl
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Medina Lozano, Elena
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Ortega, Guillermo José
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del Pozo Vegas, Carlos
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Carbajosa Rodríguez, Virginia
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Castro Villamor, Miguel Ángel
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Sánchez Soberon, Irene
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Sanz García, Ancor
dc.date.available
2022-06-24T19:12:10Z
dc.date.issued
2020-07
dc.identifier.citation
Martín Rodríguez, Francisco; López Izquierdo, Raúl; Medina Lozano, Elena; Ortega, Guillermo José; del Pozo Vegas, Carlos; et al.; Accuracy of prehospital point-of-care lactate in early in-hospital mortality; Wiley Blackwell Publishing, Inc; European Journal of Clinical Investigation; 50; 12; 7-2020; 1-10
dc.identifier.issn
0014-2972
dc.identifier.uri
http://hdl.handle.net/11336/160533
dc.description.abstract
Background: Emergency medical services (EMS) routinely face complex scenarios where decisions should be taken with limited clinical information. The development of fast, reliable and easy to perform warning biomarkers could help in such decision-making processes. The present study aims at characterizing the validity of point-of-care lactate (pLA) during prehospital tasks for predicting in-hospital mortality within two days after the EMS assistance. Materials and methods: Prospective, multicentric, ambulance-based and controlled observational study without intervention, including six advanced life support and five hospitals. The pLA levels were recorded during EMS assistance of adult patients. The validity of pLA to determine the in-hospital mortality was assessed by the area under the curve (AUC) of the receiver operating curve (ROC). Results: A total of 2997 patients were considered in the study, with a median of 69 years (IQR 54-81) and 41.4% of women. The median pLA value was 2.7 mmol/L (1.9-3.8) in survivors and 5.7 mmol/L (4.4-7.6) in nonsurvivors. The global discrimination level of pLA reached an AUC of 0.867, being 1.9 mmol/L and 4 mmol/L the cut-off point for low and high mortality. The discrimination value of pLA was not affected by sex, age or pathology. Conclusions: Our results highlight the clinical importance of prehospital pLA to determine the in-hospital risk of mortality. The incorporation of pLA into the EMS protocols could improve the early identification of risky patients, leading to a better care of such patients.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CLINICAL CLERKSHIP
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CRITICAL CARE
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EMERGENCY MEDICAL SERVICES
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LACTATE
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POINT-OF-CARE TESTING
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Otras Medicina Clínica
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Accuracy of prehospital point-of-care lactate in early in-hospital mortality
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-06-24T17:22:26Z
dc.journal.volume
50
dc.journal.number
12
dc.journal.pagination
1-10
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Martín Rodríguez, Francisco. Universidad de Valladolid; España. Paseo Hospital Militar; España
dc.description.fil
Fil: López Izquierdo, Raúl. Universidad de Valladolid; España. Hospital Universitario Rio Hortega; España
dc.description.fil
Fil: Medina Lozano, Elena. Universidad de Valladolid; España
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Fil: Ortega, Guillermo José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Autonoma de Madrid. Hospital Universitario de la Princesa; España
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Fil: del Pozo Vegas, Carlos. Hospital Clínico Universitario; España
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Fil: Carbajosa Rodríguez, Virginia. Hospital Universitario Rio Hortega; España
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Fil: Castro Villamor, Miguel Ángel. Universidad de Valladolid; España
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Fil: Sánchez Soberon, Irene. Paseo Hospital Militar; España
dc.description.fil
Fil: Sanz García, Ancor. Universidad Autonoma de Madrid. Hospital Universitario de la Princesa; España
dc.journal.title
European Journal of Clinical Investigation
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/eci.13341
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/eci.13341
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