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dc.contributor.author Gotelli, Gustavo A.
dc.contributor.author Bonelli, Pablo Ricardo
dc.contributor.author Abraham, Gustavo Abel
dc.contributor.author Sosnik, Alejandro Dario
dc.date.available 2017-05-05T17:51:56Z
dc.date.issued 2011-08
dc.identifier.citation Gotelli, Gustavo A.; Bonelli, Pablo Ricardo; Abraham, Gustavo Abel; Sosnik, Alejandro Dario; Fast and efficient synthesis of high molecular weight poly(e-caprolactone) diols by Microwave-Assisted Polymer Synthesis (MAPS); Wiley; Journal Of Applied Polymer Science; 121; 3; 8-2011; 1321-1329
dc.identifier.issn 0021-8995
dc.identifier.uri http://hdl.handle.net/11336/16032
dc.description.abstract Due to advantageous features such as shorter reaction times, greater yields, limited generation of by-products and relatively easy scale-up without detrimental effects, microwave-assisted synthesis has become a very appealing tool in organic synthesis. On the other hand, its implementation in the context of the synthesis of biomaterials for biopharmaceutical applications has been more limited. The present work reports on the fast and efficient microwave-assisted synthesis of poly(ethylene glycol) (PEG)-initiated poly(epsilon-caprolactone) diols (PCL) by the ring-opening polymerization (ROP) of epsilon-caprolactone using stannous octanoate as the catalyst. Since the PEG content in the synthesized copolymers was extremely low (0.2-1.9%), products were highly hydrophobic and displayed the intrinsic physicochemical and thermal properties of pure PCL. As opposed to the more time–consuming conventional thermally-driven synthesis that usually demands 2-3 h, the microwave technique resulted in high molecular weight PCL derivatives within 10-15 min. The influence of different parameters affecting the synthetic process, namely monomer-to-initiator ratio, reaction time, catalyst concentration and the presence, type and concentration of solvent were thoroughly investigated.
dc.format application/pdf
dc.language.iso eng
dc.publisher Wiley
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject MICROWAVE-ASSISTED POLYMER SYNTHESIS
dc.subject POLYESTERS
dc.subject BIOMATERIALS
dc.subject.classification Bioproductos, Biomateriales, Bioplásticos, Biocombustibles, Bioderivados, etc.
dc.subject.classification Biotecnología Industrial
dc.subject.classification INGENIERÍAS Y TECNOLOGÍAS
dc.title Fast and efficient synthesis of high molecular weight poly(e-caprolactone) diols by Microwave-Assisted Polymer Synthesis (MAPS)
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-02-06T14:30:59Z
dc.journal.volume 121
dc.journal.number 3
dc.journal.pagination 1321-1329
dc.journal.pais Estados Unidos
dc.journal.ciudad Hoboken
dc.description.fil Fil: Gotelli, Gustavo A.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
dc.description.fil Fil: Bonelli, Pablo Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones En Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones En Ciencia y Tecnología de Materiales; Argentina
dc.description.fil Fil: Sosnik, Alejandro Dario. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title Journal Of Applied Polymer Science
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/app.33664
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/app.33664/full


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)