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dc.contributor.author
Caracciolo, Pablo Christian
dc.contributor.author
Buffa, Juan Manuel
dc.contributor.author
Thomas, Vinoy
dc.contributor.author
Vohra, Yogesh K.
dc.contributor.author
Abraham, Gustavo Abel
dc.date.available
2017-05-05T17:45:32Z
dc.date.issued
2011-09
dc.identifier.citation
Caracciolo, Pablo Christian; Buffa, Juan Manuel; Thomas, Vinoy; Vohra, Yogesh K.; Abraham, Gustavo Abel; Biodegradable polyurethanes: Comparative study of electrospun scaffolds and films; Wiley; Journal Of Applied Polymer Science; 121; 6; 9-2011; 3292-3299
dc.identifier.issn
0021-8995
dc.identifier.uri
http://hdl.handle.net/11336/16030
dc.description.abstract
The development of elastomeric bioresorbable and biocompatible segmented polyurethanes (SPU) for use in tissue engineering applications has been a subject of considerable interest in recent years. In this work, non-porous films and micro/nanofibrous scaffolds prepared from two different poly(ε-caprolactone)-based SPU previously synthesized using 1,6-hexamethylene diisocyanate and novel chain extenders containing urea groups or an aromatic aminoacid derivative, were studied. Thermal properties were influenced both by the different chemical structure of the hard segments and the processing conditions. Mechanical properties of the scaffolds showed elastic moludus, ultimate strain and tensile stress values adecuate for soft-tissue engineered constructs (i.e.: myocardial tissue). Film samples displayed low swelling degree (less than 2 wt %) in phosphate-buffered solution (PBS) at 37 ºC. The introduction of the aminoacid derivative chain extender with hydrolyzable ester bonds contributed to a higher degradation. Fibrous scaffolds exhibited higher hydrolytic stability than films at short times of assay, due to their more crystalline structures and higher degrees of association by hydrogen bonding, but also higher mass loss values in accelerated conditions (70 ºC), suggesting that degradation rate is not constant but depends on the degradation time and the processing technique.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Nanofibers
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Scaffold
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Thermal Properties
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Mechanical Properties
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Degradation
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Polyurethanes
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Otras Ingeniería de los Materiales
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Ingeniería de los Materiales
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INGENIERÍAS Y TECNOLOGÍAS
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Bioproductos, Biomateriales, Bioplásticos, Biocombustibles, Bioderivados, etc.
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Biotecnología Industrial
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
Biodegradable polyurethanes: Comparative study of electrospun scaffolds and films
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-02-06T14:30:04Z
dc.journal.volume
121
dc.journal.number
6
dc.journal.pagination
3292-3299
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Hoboken
dc.description.fil
Fil: Caracciolo, Pablo Christian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones En Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones En Ciencia y Tecnología de Materiales; Argentina
dc.description.fil
Fil: Buffa, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones En Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones En Ciencia y Tecnología de Materiales; Argentina
dc.description.fil
Fil: Thomas, Vinoy. University Of Alabama At Birmingahm; Estados Unidos
dc.description.fil
Fil: Vohra, Yogesh K.. University Of Alabama At Birmingahm; Estados Unidos
dc.description.fil
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones En Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones En Ciencia y Tecnología de Materiales; Argentina
dc.journal.title
Journal Of Applied Polymer Science
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/app.33855/abstract?userIsAuthenticated=false&deniedAccessCustomisedMessage=
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/app.33855


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