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dc.contributor.author
López, L.
dc.contributor.author
Flichman, Diego Martin
dc.contributor.author
Mojsiejczuk, Laura Noelia
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Gonzalez, M. V.
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Uriarte, R.
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Campos, Rodolfo Hector
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Cristina, J.
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García Aguirre, L.
dc.date.available
2017-05-05T15:51:13Z
dc.date.issued
2015-06
dc.identifier.citation
López, L.; Flichman, Diego Martin; Mojsiejczuk, Laura Noelia; Gonzalez, M. V.; Uriarte, R.; et al.; Genetic variability of hepatitis B virus in Uruguay: D/F, A/F genotype recombinants; Springer Wien; Archives of Virology; 160; 9; 6-2015; 2209-2217
dc.identifier.issn
0304-8608
dc.identifier.uri
http://hdl.handle.net/11336/16024
dc.description.abstract
Hepatitis B virus (HBV) infection is a serious global health problem. Approximately 2 billion people worldwide have been infected, and approximately 350 million individuals currently suffer from HBV-induced chronic liver infection, which causes 600,000 deaths annually from chronic hepatitis, cirrhosis and hepatocellular carcinoma. HBV is classified in eight genotypes (A-H), and two more have been proposed (I-J). In this paper, complete genome sequences of nine Uruguayan HBV are reported. Five samples belong to genotype F1b and one to genotype A2. Three HBV recombinants were detected: A1/F1b, A2/F1b and D3/F1b. The following mutations were detected: a G1896A substitution, a 33-nucleotide deletion from position 2896 to 2928 in the Pre-S1 region involving Pre-S1 residues 3-13, a 33-nt deletion in the Pre-S1 region involving nt 2913-2945 and Pre-S1 residues 9-19. More F genotypes strains than expected were detected in this study, supporting the hypothesis that there are more people of indigenous origin than declared in our population. Also, one third of the samples analyzed were recombinants. This cannot be explained by the low HBV prevalence in Uruguay, but a high HBV infection rate in drug addicts and dialysis patients could act in favor of multiple-genotype HBV infections that could lead to recombination.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer Wien
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Hepatitis B Virus
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Genotypes Recombinants
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Uruguay
dc.subject.classification
Enfermedades Infecciosas
dc.subject.classification
Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Genetic variability of hepatitis B virus in Uruguay: D/F, A/F genotype recombinants
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-04-28T17:10:31Z
dc.identifier.eissn
1432-8798
dc.journal.volume
160
dc.journal.number
9
dc.journal.pagination
2209-2217
dc.journal.pais
Austria
dc.journal.ciudad
Viena
dc.description.fil
Fil: López, L.. Universidad de la República; Uruguay
dc.description.fil
Fil: Flichman, Diego Martin. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Mojsiejczuk, Laura Noelia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Gonzalez, M. V.. Centro Hospitalario Pereira Rossell. Departamento de Patología Clínica. Laboratorio de Inmunología; Uruguay
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Fil: Uriarte, R.. Asociación Española. Laboratorio de Biología Molecular; Uruguay
dc.description.fil
Fil: Campos, Rodolfo Hector. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Cristina, J.. Universidad de la República; Uruguay
dc.description.fil
Fil: García Aguirre, L.. Universidad de la República; Uruguay
dc.journal.title
Archives of Virology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00705-015-2477-0
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00705-015-2477-0
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