Artículo
Classical and non-classical thyroid hormone intracellular pathways involved in T lymphoma growth
Barreiro Arcos, María Laura
; Sterle, Helena Andrea
; Cayrol, Maria Florencia
; Díaz Flaqué, María Celeste
; Valli, Eduardo
; Paulazo, Maria Alejandra
; Klecha, Alicia Juana
; Cremaschi, Graciela Alicia
Fecha de publicación:
04/2015
Editorial:
Bentham Science Publishers
Revista:
Inmunology, Endocrine & Metabolic Agents in Medicinal Chemistry
ISSN:
1871-5222
e-ISSN:
1875-5844
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Thyroid hormones (THs) are important regulators of cell physiology. They are essential for the normal development and growth of mammals, especially for the neural differentiation and the regulation of the metabolism and the immune system. THs also induce the proliferation of several cell types. In human and murine T cell lymphomas (TCL) this effect involves the participation of genomic and nongenomic mechanisms as it was described by the use of free THs and non-cell permeable THs coupled to agarose (TH-ag). The classic actions of thyroid hormones involve the alteration of gene transcription via specific nuclear receptors. The discovery of other effects, independent of this classic mechanism, characterizes a new and non-classic mechanism that involves different signaling pathways. Both, free THs and TH-ag, activate protein kinase C, extracellular signalregulated kinases and NF-kB and they increase the intracellular calcium levels. However, only the preincubation of T cells with free THs leads to an increased intracellular content of signaling enzymes. T lymphomas display high expression levels of both, the TH nuclear receptors (TRs) and the putative membrane receptor for THs, the integrin αvβ3, which has been demonstrated to be responsible for THs non-genomic actions. Here, we reviewed the mechanisms involved in THs modulation of the lymphocyte physiology, analyzing the interplay between genomic and nongenomic actions in T cells and its contribution in the development of lymphomas.
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Articulos(BIOMED)
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Barreiro Arcos, María Laura; Sterle, Helena Andrea; Cayrol, Maria Florencia; Díaz Flaqué, María Celeste; Valli, Eduardo; et al.; Classical and non-classical thyroid hormone intracellular pathways involved in T lymphoma growth; Bentham Science Publishers; Inmunology, Endocrine & Metabolic Agents in Medicinal Chemistry; 15; 1; 4-2015; 37-42
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