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dc.contributor.author
Merico, Valeria  
dc.contributor.author
Luaces, Juan Pablo  
dc.contributor.author
Rossi, Luis Francisco  
dc.contributor.author
Rebuzzini, Paola  
dc.contributor.author
Merani, Maria Susana  
dc.contributor.author
Zuccotti, Maurizio  
dc.contributor.author
Garagna, Silvia  
dc.date.available
2022-06-22T13:23:08Z  
dc.date.issued
2019-01  
dc.identifier.citation
Merico, Valeria; Luaces, Juan Pablo; Rossi, Luis Francisco; Rebuzzini, Paola; Merani, Maria Susana; et al.; Sertoli–immature spermatids disengagement during testis regression in the armadillo; BioScientifica; Reproduction; 157; 1; 1-2019; 27-42  
dc.identifier.issn
1470-1626  
dc.identifier.uri
http://hdl.handle.net/11336/160168  
dc.description.abstract
In nature, mammalian seasonal breeders undergo spermatogenetic arrest during the non-breeding season. In the large hairy armadillo Chaetophractus villosus, testis regression initiates with immature post-meiotic germ cells sloughing into the tubule lumen and continues with the death of the remaining spermatocytes. At the end of the regression period, only spermatogonia and Sertoli cells persist in the seminiferous epithelium. It has been suggested that cell sloughing is determined by changes in the adhesion complexes between Sertoli cells and spermatids, which are mediated by low intra-testicular testosterone levels. By immunofluorescence and Western blotting we studied key proteins of the N-cadherin/N-cadherin and A6B1-integrin/laminin interlocks that contribute to the complex Sertoli/spermatid adhesion system throughout the eight stages of the seminiferous epithelium cycle in the comparison between active and regressing testes. In active testis, B1-integrin, laminin G3, N-cadherin, B-catenin, P-B-catenin-Tyr654, FAK, P-FAK-Tyr397, SRC, P-SRC-Tyr416 proteins present a spermatogenetic cycle-dependent localisation pattern, unmaintained in regressing testes. In the latter, quantitative variations and changes in the phosphorylation state of protein FAK, SRC and B-catenin contribute to the disassembly of the N-cadherin/N-cadherin and A6B1-integrin/laminin interlocks, thus promoting the massive release of immature spermatids.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
BioScientifica  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Seasonal reproduction  
dc.subject
armadillo  
dc.subject
spermatogenesis  
dc.subject
testis regression  
dc.subject
adherens junctions  
dc.subject.classification
Biología Reproductiva  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Sertoli–immature spermatids disengagement during testis regression in the armadillo  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2022-06-21T19:33:41Z  
dc.journal.volume
157  
dc.journal.number
1  
dc.journal.pagination
27-42  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Bristol  
dc.description.fil
Fil: Merico, Valeria. Universita degli Studi di Pavia; Italia  
dc.description.fil
Fil: Luaces, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina  
dc.description.fil
Fil: Rossi, Luis Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina  
dc.description.fil
Fil: Rebuzzini, Paola. Universita degli Studi di Pavia; Italia  
dc.description.fil
Fil: Merani, Maria Susana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina  
dc.description.fil
Fil: Zuccotti, Maurizio. Universita degli Studi di Pavia; Italia  
dc.description.fil
Fil: Garagna, Silvia. Universita degli Studi di Pavia; Italia  
dc.journal.title
Reproduction  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1530/REP-18-0006  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://rep.bioscientifica.com/configurable/content/journals$002frep$002f157$002f1$002fREP-18-0006.xml?t:ac=journals%24002frep%24002f157%24002f1%24002fREP-18-0006.xml