Artículo
Inoculated mammary carcinoma-associated fibroblasts: contribution to hormone independent tumor growth
Fabris, Victoria Teresa
; Sahores, Ana
; Vanzulli, Silvia; Colombo, Lucas Luis
; Molinolo, Alfredo; Lanari, Claudia Lee Malvina
; Lamb, Caroline Ana
Fecha de publicación:
2010
Editorial:
BioMed Central
Revista:
BMC Cancer
ISSN:
1471-2407
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Increasing evidence has underscored the role of carcinoma associated fibroblasts (CAF) in tumor growth. However, there are controversial data regarding the persistence of inoculated CAF within the tumors. We have developed a model in which murine metastatic ductal mammary carcinomas expressing estrogen and progesterone receptors transit through different stages of hormone dependency. Hormone dependent (HD) tumors grow only in the presence of progestins, whereas hormone independent (HI) variants grow without hormone supply. We demonstrated previously that CAF from HI tumors (CAF-HI) express high levels of FGF-2 and that FGF-2 induced HD tumor growth in vivo. Our main goal was to investigate whether inoculated CAF-HI combined with purified epithelial (EPI) HD cells can induce HD tumor growth.
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Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Fabris, Victoria Teresa; Sahores, Ana; Vanzulli, Silvia; Colombo, Lucas Luis; Molinolo, Alfredo; et al.; Inoculated mammary carcinoma-associated fibroblasts: contribution to hormone independent tumor growth; BioMed Central; BMC Cancer; 10; 293; 2010; 1-10
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