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Artículo

Chronic infection with the protozoan Toxoplasma gondii prevents the development of experimental atopic dermatitis in mice

Perrone Sibilia, Matías Damián; Aldirico, María de Los ÁngelesIcon ; Soto, Ariadna SoledadIcon ; Picchio, Mariano SergioIcon ; Sánchez, Vanesa RoxanaIcon ; Arcon, NadiaIcon ; Moretta, Rosalia EsterIcon ; Martín, ValentinaIcon ; Vanzulli, Silvia; Fenoy, Ignacio MartínIcon ; Goldman, AlejandraIcon
Fecha de publicación: 02/11/2019
Editorial: Elsevier Ireland
Revista: Journal of Dermatological Science
ISSN: 0923-1811
e-ISSN: 1873-569X
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Inmunología

Resumen

Background: Supporting the hypothesis thatT. gondii infection protects against allergy in humans we previously demonstrated that this infection can modulate not only the susceptibility to develop respiratory allergies in mice but also suppresses allergic responses at systemic level. This latter finding suggests that T. gondii infection could prevent the onset of other allergic diseases, such as atopic dermatitis. At present, few studies have investigated the modulation of atopic dermatitis by parasite infections. Objective: Here, we sought to investigate whether chronic infection with T. gondii is capable of modulating the development of atopic dermatitis. Methods: Chronically infected mice were sensitized by repeated epicutaneous ovalbumin administration. Skin histopathology, humoral response, cytokine production and innate type-II lymphoid cells (ILC2) were assessed. Results: A marked reduction in epidermal thickness and dermal inflammatory infiltrate along with a reduction in mast cell count was observed in infected mice compared to non-infected mice. These results correlated with a diminished TH2 and TH1 allergen specific response. Reduced type-II IL-4 and IL-5 cytokines were already detected during the first 24 h of allergen sensitization in splenocytes and draining lymph nodes from infected mice. Moreover, this reduced type-II profile in chronically infected animals correlated with diminished ILC2 number in draining lymph nodes. Conclusion: Chronic infection withT. gondii prevents the development of atopic dermatitis. The diminished susceptibility seems to result from changes in type-II innate immune response that may lead to the induction of a deficient TH2 response and consequently to a lower susceptibility to develop atopic dermatitis.
Palabras clave: ALLERGY , ATOPIC DERMATITIS , IMMUNOMODULATION , TOXOPLASMA GONDII
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/159506
URL: https://www.jdsjournal.com/article/S0923-1811(19)30339-1/fulltext
DOI: http://dx.doi.org/10.1016/j.jdermsci.2019.10.007
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Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Perrone Sibilia, Matías Damián; Aldirico, María de Los Ángeles; Soto, Ariadna Soledad; Picchio, Mariano Sergio; Sánchez, Vanesa Roxana; et al.; Chronic infection with the protozoan Toxoplasma gondii prevents the development of experimental atopic dermatitis in mice; Elsevier Ireland; Journal of Dermatological Science; 96; 3; 2-11-2019; 143-150
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