Binary systems of albendazole desmotropes with amino-acids: Experimental and theoretical studies

Abstract

In this work, new binary systems of albendazole desmotropes with amino-acids were developed and investigated. In particular, solubility studies evidenced that aspartic acid and glutamic acid were the most important enhancer ligands. The molecular interactions were examined by nuclear magnetic resonance and molecular modeling techniques, which revealed that the binary systems are stabilized by several intermolecular H-bonds. Solid samples were prepared by kneading method and physical mixture. It was characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, thermal analysis and solubility studies. The results obtained showed that the binary systems significantly incremented the saturation solubility in water and simulated gastric fluid compared to free desmotrope. In conclusion, the enhancement of biopharmaceutical properties evidenced that these novel systems are promising candidates for the development of oral formulations for delivery of the drug.