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dc.contributor.author
Tirado González, Irene
dc.contributor.author
Freitag, Nancy
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Barrientos, Gabriela Laura
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Shaikly, Valerie
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Nagaeva, Olga
dc.contributor.author
Strand, Magnus
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Kjellberg, Lennart
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Klapp, Burghard F.
dc.contributor.author
Mincheva Nilsson, Lucia
dc.contributor.author
Cohen, Marie
dc.contributor.author
Blois, Sandra M.
dc.date.available
2017-05-03T19:59:13Z
dc.date.issued
2013-01
dc.identifier.citation
Tirado González, Irene; Freitag, Nancy; Barrientos, Gabriela Laura; Shaikly, Valerie; Nagaeva, Olga; et al.; Galectin-1 influences trophoblast immune evasion and emerges as a predictive factor for the outcome of pregnancy; Oxford University Press; Molecular Human Reproduction; 19; 1; 1-2013; 43-53
dc.identifier.issn
1360-9947
dc.identifier.uri
http://hdl.handle.net/11336/15939
dc.description.abstract
Galectin-1 (gal-1) is expressed at the feto-maternal interface and plays a role in regulating the maternal immune response against placental alloantigens, contributing to pregnancy maintenance. Both decidua and placenta contribute to gal-1 expression and may be important for the maternal immune regulation. The expression of gal-1 within the placenta is considered relevant to cell-adhesion and invasion of trophoblasts, but the role of gal-1 in the immune evasion machinery exhibited by trophoblast cells remains to be elucidated. In this study, we analyzed gal-1 expression in preimplantation human embryos and first-trimester decidua-placenta specimens and serum gal-1 levels to investigate the physiological role played by this lectin during pregnancy. The effect on human leukocyte antigen G (HLAG) expression in response to stimulation or silencing of gal-1 was also determined in the human invasive, proliferative extravillous cytotrophoblast 65 (HIPEC65) cell line. Compared with normal pregnant women, circulating gal-1 levels were significantly decreased in patients who subsequently suffered a miscarriage. Human embryos undergoing preimplantation development expressed gal-1 on the trophectoderm and inner cell mass. Furthermore, our in vitro experiments showed that exogenous gal-1 positively regulated the membrane-bound HLA-G isoforms (HLA-G1 and G2) in HIPEC65 cells, whereas endogenous gal-1 also induced expression of the soluble isoforms (HLA-G5 and -G6). Our results suggest that gal-1 plays a key role in pregnancy maternal immune regulation by modulating HLA-G expression on trophoblast cells. Circulating gal-1 levels could serve as a predictive factor for pregnancy success in early human gestation.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford University Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Gal-1
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Hla-G
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Human Embryo
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Spontaneous Abortion
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Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Galectin-1 influences trophoblast immune evasion and emerges as a predictive factor for the outcome of pregnancy
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-05-02T20:58:33Z
dc.journal.volume
19
dc.journal.number
1
dc.journal.pagination
43-53
dc.journal.pais
Reino Unido
dc.journal.ciudad
Oxford
dc.description.fil
Fil: Tirado González, Irene. Medicine University Berlin; Alemania
dc.description.fil
Fil: Freitag, Nancy. Medicine University Berlin; Alemania
dc.description.fil
Fil: Barrientos, Gabriela Laura. Medicine University Berlin; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Shaikly, Valerie. University Of Essex; Reino Unido. Assisted Reproduction and Gynaecology Centre; Reino Unido
dc.description.fil
Fil: Nagaeva, Olga. Universidad de Umea; Suecia
dc.description.fil
Fil: Strand, Magnus. Universidad de Umea; Suecia
dc.description.fil
Fil: Kjellberg, Lennart. Universidad de Umea; Suecia
dc.description.fil
Fil: Klapp, Burghard F.. Medicine University Berlin; Alemania
dc.description.fil
Fil: Mincheva Nilsson, Lucia. Universidad de Umea; Suecia
dc.description.fil
Fil: Cohen, Marie. Laboratoire d’Hormonologie; Suiza
dc.description.fil
Fil: Blois, Sandra M.. Medicine University Berlin; Alemania
dc.journal.title
Molecular Human Reproduction
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/molehr/gas043
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/molehr/article-lookup/doi/10.1093/molehr/gas043
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