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dc.contributor.author
Berra Romani, Roberto
dc.contributor.author
Raqeeb, Abdul
dc.contributor.author
Avelino Cruz, José Everardo
dc.contributor.author
Moccia, Francesco
dc.contributor.author
Oldani, Amanda
dc.contributor.author
Speroni Aguirre, Francisco José
dc.contributor.author
Taglietti, Vanni
dc.contributor.author
Tanzi, Franco
dc.date.available
2022-06-09T12:34:51Z
dc.date.issued
2008-09
dc.identifier.citation
Berra Romani, Roberto; Raqeeb, Abdul; Avelino Cruz, José Everardo; Moccia, Francesco; Oldani, Amanda; et al.; Ca2+ signaling in injured in situ endothelium of rat aorta; Elsevier; Cell Calcium; 44; 3; 9-2008; 298-309
dc.identifier.issn
0143-4160
dc.identifier.uri
http://hdl.handle.net/11336/159337
dc.description.abstract
The inner wall of excised rat aorta was scraped by a microelectrode and Ca2+ signals were investigated by fluorescence microscopy in endothelial cells (ECs) directly coupled with injured cells. The injury caused an immediate increase in the intracellular Ca2+ concentration ([Ca2+]i), followed by a long-lasting decay phase due to Ca2+ influx from extracellular space. The immediate response was mainly due to activation of purinergic receptors, as shown by the effect of P2X and P2Y receptors agonists and antagonists, such as suramin, α,β-MeATP, MRS-2179 and 2-MeSAMP. Inhibition of store-operated Ca2+ influx did not affect either the peak response or the decay phase. Furthermore, the latter was: (i) insensitive to phospholipase C inhibition, (ii) sensitive to the gap junction blockers, palmitoleic acid, heptanol, octanol and oleamide, and (iii) sensitive to La3+ and Ni2+, but not to Gd3+. Finally, ethidium bromide or Lucifer Yellow did not enter ECs facing the scraped area. These results suggest that endothelium scraping: (i) causes a short-lasting stimulation of healthy ECs by extracellular nucleotides released from damaged cells and (ii) uncouples the hemichannels of the ECs facing the injury site; these hemichannels do not fully close and allow a long-lasting Ca2+ entry.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ATP
dc.subject
CA2+
dc.subject
GAP JUNCTIONS
dc.subject
IN SITU ENDOTHELIUM
dc.subject
INJURY
dc.subject
RAT AORTA
dc.subject.classification
Alimentos y Bebidas
dc.subject.classification
Otras Ingenierías y Tecnologías
dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
dc.title
Ca2+ signaling in injured in situ endothelium of rat aorta
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-05-12T16:32:38Z
dc.identifier.eissn
1532-1991
dc.journal.volume
44
dc.journal.number
3
dc.journal.pagination
298-309
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Berra Romani, Roberto. Universita degli Studi di Pavia; Italia
dc.description.fil
Fil: Raqeeb, Abdul. Universita degli Studi di Pavia; Italia
dc.description.fil
Fil: Avelino Cruz, José Everardo. Universita degli Studi di Pavia; Italia
dc.description.fil
Fil: Moccia, Francesco. Universita degli Studi di Pavia; Italia
dc.description.fil
Fil: Oldani, Amanda. Universita degli Studi di Pavia; Italia
dc.description.fil
Fil: Speroni Aguirre, Francisco José. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos; Argentina. Universita degli Studi di Pavia; Italia
dc.description.fil
Fil: Taglietti, Vanni. Universita degli Studi di Pavia; Italia
dc.description.fil
Fil: Tanzi, Franco. Universita degli Studi di Pavia; Italia
dc.journal.title
Cell Calcium
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0143416007002138
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ceca.2007.12.007
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