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dc.contributor.author
Perez, Laura Garcia
dc.contributor.author
Kempski, Jan
dc.contributor.author
McGee, Heather M.
dc.contributor.author
Pelzcar, Penelope
dc.contributor.author
Agalioti, Theodora
dc.contributor.author
Giannou, Anastasios
dc.contributor.author
Konczalla, Leonie
dc.contributor.author
Brockmann, Leonie
dc.contributor.author
Wahib, Ramez
dc.contributor.author
Xu, Hao
dc.contributor.author
Amezcua Vesely, Maria Carolina
dc.contributor.author
Soukou, Shiwa
dc.contributor.author
Steglich, Babett
dc.contributor.author
Bedke, Tanja
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Manthey, Carolin
dc.contributor.author
Seiz, Oliver
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Diercks, Björn-Philipp
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Gnafakis, Stylianos
dc.contributor.author
Guse, Andreas H.
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Perez, Daniel
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Izbicki, Jakob R.
dc.contributor.author
Gagliani, Nicola
dc.contributor.author
Flavell, Richard A.
dc.contributor.author
Huber, Samuel
dc.date.available
2022-06-08T13:57:54Z
dc.date.issued
2020-05
dc.identifier.citation
Perez, Laura Garcia; Kempski, Jan; McGee, Heather M.; Pelzcar, Penelope; Agalioti, Theodora; et al.; TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer; Nature Research; Nature Communications; 11; 1; 5-2020; 1-14
dc.identifier.uri
http://hdl.handle.net/11336/159230
dc.description.abstract
IL-22 has dual functions during tumorigenesis. Short term IL-22 production protects against genotoxic stress, whereas uncontrolled IL-22 activity promotes tumor growth; therefore, tight regulation of IL-22 is essential. TGF-β1 promotes the differentiation of Th17 cells, which are known to be a major source of IL-22, but the effect of TGF-β signaling on the production of IL-22 in CD4+ T cells is controversial. Here we show an increased presence of IL-17+IL-22+ cells and TGF-β1 in colorectal cancer compared to normal adjacent tissue, whereas the frequency of IL-22 single producing cells is not changed. Accordingly, TGF-β signaling in CD4+ T cells (specifically Th17 cells) promotes the emergence of IL-22-producing Th17 cells and thereby tumorigenesis in mice. IL-22 single producing T cells, however, are not dependent on TGF-β signaling. We show that TGF-β, via AhR induction, and PI3K signaling promotes IL-22 production in Th17 cells.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Research
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
TGFb
dc.subject
IL-22
dc.subject
Th17
dc.subject
AhR
dc.subject.classification
Inmunología
dc.subject.classification
Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-09-06T15:12:21Z
dc.identifier.eissn
2041-1723
dc.journal.volume
11
dc.journal.number
1
dc.journal.pagination
1-14
dc.journal.pais
Reino Unido
dc.description.fil
Fil: Perez, Laura Garcia. Department Of Medicine, University Medical Center Hamb; Alemania
dc.description.fil
Fil: Kempski, Jan. Universitat Hamburg; Alemania
dc.description.fil
Fil: McGee, Heather M.. Universitat Hamburg; Alemania
dc.description.fil
Fil: Pelzcar, Penelope. Universitat Hamburg; Alemania
dc.description.fil
Fil: Agalioti, Theodora. Universitat Hamburg; Alemania
dc.description.fil
Fil: Giannou, Anastasios. Universitat Hamburg; Alemania
dc.description.fil
Fil: Konczalla, Leonie. Universitat Hamburg; Alemania
dc.description.fil
Fil: Brockmann, Leonie. Universitat Hamburg; Alemania
dc.description.fil
Fil: Wahib, Ramez. Universitat Hamburg; Alemania
dc.description.fil
Fil: Xu, Hao. University of Yale. School of Medicine; Estados Unidos
dc.description.fil
Fil: Amezcua Vesely, Maria Carolina. University of Yale. School of Medicine; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Soukou, Shiwa. Universitat Hamburg; Alemania
dc.description.fil
Fil: Steglich, Babett. Universitat Hamburg; Alemania
dc.description.fil
Fil: Bedke, Tanja. Universitat Hamburg; Alemania
dc.description.fil
Fil: Manthey, Carolin. Universitat Hamburg; Alemania
dc.description.fil
Fil: Seiz, Oliver. Universitat Hamburg; Alemania
dc.description.fil
Fil: Diercks, Björn-Philipp. Universitat Hamburg; Alemania
dc.description.fil
Fil: Gnafakis, Stylianos. Universitat Hamburg; Alemania
dc.description.fil
Fil: Guse, Andreas H.. Universitat Hamburg; Alemania
dc.description.fil
Fil: Perez, Daniel. Universitat Hamburg; Alemania
dc.description.fil
Fil: Izbicki, Jakob R.. Universitat Hamburg; Alemania
dc.description.fil
Fil: Gagliani, Nicola. Universitat Hamburg; Alemania
dc.description.fil
Fil: Flavell, Richard A.. University of Yale. School of Medicine; Estados Unidos
dc.description.fil
Fil: Huber, Samuel. Universitat Hamburg; Alemania
dc.journal.title
Nature Communications
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41467-020-16363-w
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/s41467-020-16363-w
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