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dc.contributor.author
Pandey, Pooja
dc.contributor.author
Leary, Alexandre Y.
dc.contributor.author
Tumtas, Yasin
dc.contributor.author
Savage, Zachary
dc.contributor.author
Dagvadorj, Bayantes
dc.contributor.author
Duggan, Cian
dc.contributor.author
Yuen, Enoch L.H.
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Sanguankiattichai, Nattapong
dc.contributor.author
Tan, Emily
dc.contributor.author
Khandare, Virendrasinh
dc.contributor.author
Connerton, Amber J.
dc.contributor.author
Yunusov, Temur
dc.contributor.author
Madalinski, Mathias
dc.contributor.author
Mirkin, Federico Gabriel
dc.contributor.author
Schornack, Sebastian
dc.contributor.author
Dagdas, Yasin
dc.contributor.author
Kamoun, Sophien
dc.contributor.author
Bozkurt, Osman Tolga
dc.date.available
2022-06-03T10:22:32Z
dc.date.issued
2021-08-23
dc.identifier.citation
Pandey, Pooja; Leary, Alexandre Y.; Tumtas, Yasin; Savage, Zachary; Dagvadorj, Bayantes; et al.; An oomycete effector subverts host vesicle trafficking to channel starvation-induced autophagy to the pathogen interface; eLife Sciences Publications Ltd; eLife; 10; 23-8-2021; 1-35
dc.identifier.issn
2050-084X
dc.identifier.uri
http://hdl.handle.net/11336/158819
dc.description.abstract
Eukaryotic cells deploy autophagy to eliminate invading microbes. In turn, pathogens have evolved effector proteins to counteract antimicrobial autophagy. How adapted pathogens co-opt autophagy for their own benefit is poorly understood. The Irish famine pathogen Phytophthora infestans secretes the effector protein PexRD54 that selectively activates an unknown plant autophagy pathway that antagonizes antimicrobial autophagy at the pathogen interface. Here, we show that PexRD54 induces autophagosome formation by bridging vesicles decorated by the small GTPase Rab8a with autophagic compartments labeled by the core autophagy protein ATG8CL. Rab8a is required for pathogen-triggered and starvation-induced but not antimicrobial autophagy, revealing specific trafficking pathways underpin selective autophagy. By subverting Rab8a-mediated vesicle trafficking, PexRD54 utilizes lipid droplets to facilitate biogenesis of autophagosomes diverted to pathogen feeding sites. Altogether, we show that PexRD54 mimics starvation-induced autophagy to subvert endomembrane trafficking at the host-pathogen interface, revealing how effectors bridge distinct host compartments to expedite colonization.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
eLife Sciences Publications Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
PHYTOPHTHORA INFESTANS
dc.subject
AUTOPHAGY
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EFFECTOR
dc.subject
RAB8
dc.subject.classification
Biología Celular, Microbiología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
An oomycete effector subverts host vesicle trafficking to channel starvation-induced autophagy to the pathogen interface
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-05-06T16:04:23Z
dc.journal.volume
10
dc.journal.pagination
1-35
dc.journal.pais
Reino Unido
dc.journal.ciudad
Cambridge
dc.description.fil
Fil: Pandey, Pooja. Imperial College London; Reino Unido
dc.description.fil
Fil: Leary, Alexandre Y.. Imperial College London; Reino Unido
dc.description.fil
Fil: Tumtas, Yasin. Imperial College London; Reino Unido
dc.description.fil
Fil: Savage, Zachary. Imperial College London; Reino Unido
dc.description.fil
Fil: Dagvadorj, Bayantes. Imperial College London; Reino Unido
dc.description.fil
Fil: Duggan, Cian. Imperial College London; Reino Unido
dc.description.fil
Fil: Yuen, Enoch L.H.. Imperial College London; Reino Unido
dc.description.fil
Fil: Sanguankiattichai, Nattapong. Imperial College London; Reino Unido
dc.description.fil
Fil: Tan, Emily. Imperial College London; Reino Unido
dc.description.fil
Fil: Khandare, Virendrasinh. Imperial College London; Reino Unido
dc.description.fil
Fil: Connerton, Amber J.. Imperial College London; Reino Unido
dc.description.fil
Fil: Yunusov, Temur. University of Cambridge; Reino Unido
dc.description.fil
Fil: Madalinski, Mathias. Gregor Mendel Institute; Austria
dc.description.fil
Fil: Mirkin, Federico Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
dc.description.fil
Fil: Schornack, Sebastian. University of Cambridge; Reino Unido
dc.description.fil
Fil: Dagdas, Yasin. Gregor Mendel Institute; Austria
dc.description.fil
Fil: Kamoun, Sophien. University of East Anglia; Reino Unido
dc.description.fil
Fil: Bozkurt, Osman Tolga. Imperial College London; Reino Unido
dc.journal.title
eLife
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://elifesciences.org/articles/65285
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.7554/eLife.65285
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