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dc.contributor.author
Lee, W. K.
dc.contributor.author
Kim, Won Gu
dc.contributor.author
Fozzatti, Laura
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dc.contributor.author
Park, Sunmi
dc.contributor.author
Zhao, Li
dc.contributor.author
Willingham, Mark C.
dc.contributor.author
Lonard, David
dc.contributor.author
OMalley, Bert W.
dc.contributor.author
Cheng, Sheue-yann
dc.date.available
2022-06-02T14:37:15Z
dc.date.issued
2020-01
dc.identifier.citation
Lee, W. K.; Kim, Won Gu; Fozzatti, Laura; Park, Sunmi; Zhao, Li; et al.; Steroid receptor coactivator-3 as a target for anaplastic thyroid cancer; BioScientifica; Endocrine - Related Cancer; 27; 4; 1-2020; 209-220
dc.identifier.issn
1351-0088
dc.identifier.uri
http://hdl.handle.net/11336/158776
dc.description.abstract
Anaplastic thyroid carcinoma (ATC) is an aggressive malignancy without effective therapeutic options to improve survival. Steroid receptor coactivator-3 (SRC-3) is a transcriptional coactivator whose amplification and/or overexpression has been identified in many cancers. In this study, we explored the expression of SRC-3 in ATCs and the effects of a new class of SRC-3 inhibitor-2 (SI-2) in human ATC cells (THJ-11T and -16T cells) and mouse xenograft models to assess therapeutic potential of SI-2 for the treatment of ATC. SRC-3 protein abundance was significantly higher in human ATC tissue samples and ATC cells than in differentiated thyroid carcinomas or normal controls. SI-2 treatment effectively reduced the SRC-3 expression in both ATC cells and ATC xenograft tumors induced by these cells. Cancer cell survival in ATC cells and tumor growth in xenograft tumors were significantly reduced by SI-2 treatment through induction of cancer cell apoptosis and cell cycle arrest. SI-2 also reduced cancer stem-like cells as shown by an inhibition of tumorsphere formation, ALDH activity and expression of stem cell markers in ATC. These findings indicate that SRC-3 is a potential therapeutic target for treatment of ATC patients, and that SI-2 is a potent and promising candidate for a new therapeutic agent.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
BioScientifica
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Anaplastic Thyroid Cancer
dc.subject
Steroid receptor coactivator-3
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Cancer stem-like cells
dc.subject.classification
Otras Ciencias Médicas
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dc.subject.classification
Otras Ciencias Médicas
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Steroid receptor coactivator-3 as a target for anaplastic thyroid cancer
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-09-06T15:14:12Z
dc.identifier.eissn
1479-6821
dc.journal.volume
27
dc.journal.number
4
dc.journal.pagination
209-220
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Bristol
dc.description.fil
Fil: Lee, W. K.. National Institutes of Health; Estados Unidos
dc.description.fil
Fil: Kim, Won Gu. National Institutes of Health; Estados Unidos. University of Ulsan College of Medicine; Corea del Sur
dc.description.fil
Fil: Fozzatti, Laura. National Institutes of Health; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Park, Sunmi. National Institutes of Health; Estados Unidos
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Fil: Zhao, Li. National Institutes of Health; Estados Unidos
dc.description.fil
Fil: Willingham, Mark C.. National Institutes of Health; Estados Unidos
dc.description.fil
Fil: Lonard, David. Baylor College of Medicine; Estados Unidos
dc.description.fil
Fil: OMalley, Bert W.. Baylor College of Medicine; Estados Unidos
dc.description.fil
Fil: Cheng, Sheue-yann. National Institutes of Health; Estados Unidos
dc.journal.title
Endocrine - Related Cancer
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1530/ERC-19-0482
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://erc.bioscientifica.com/view/journals/erc/27/4/ERC-19-0482.xml
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