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dc.contributor.author
Low, Jun Siong
dc.contributor.author
Farsakoglu, Yagmur
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Amezcua Vesely, Maria Carolina
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Sefik, Esen
dc.contributor.author
Kelly, Joseph B.
dc.contributor.author
Harman, Christian C. D.
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Jackson, Ruaidhri
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Shyer, Justin A.
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Jiang, Xiaodong
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Cauley, Linda S.
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Flavell, Richard A.
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Kaech, Susan M.
dc.date.available
2022-06-01T17:36:46Z
dc.date.issued
2020-08
dc.identifier.citation
Low, Jun Siong; Farsakoglu, Yagmur; Amezcua Vesely, Maria Carolina; Sefik, Esen; Kelly, Joseph B.; et al.; Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses; Rockefeller University Press; Journal of Experimental Medicine; 217; 8; 8-2020; 1-17
dc.identifier.issn
0022-1007
dc.identifier.uri
http://hdl.handle.net/11336/158674
dc.description.abstract
CD8+ tissue-resident memory T cells (TRM cells) are poised at the portals of infection and provide long-term protective immunity. Despite their critical roles, the precise mechanics governing TRM cell reactivation in situ are unknown. Using a TCR-transgenic Nur77-GFP reporter to distinguish "antigen-specific" from "bystander" reactivation, we demonstrate that lung CD8+ TRM cells are reactivated more quickly, yet less efficiently, than their counterparts in the draining LNs (TLN cells). Global profiling of reactivated memory T cells revealed tissue-defined and temporally regulated recall response programs. Unlike the reactivation of CD8+ TLN cells, which is strictly dependent on CD11c+XCR1+ APCs, numerous antigen-presenting partners, both hematopoietic and non-hematopoietic, were sufficient to reactivate lung CD8+ TRM cells, but the quality of TRM cell functional responses depended on the identity of the APCs. Together, this work uncovers fundamental differences in the activation kinetics, mechanics, and effector responses between CD8+ memory T cells in peripheral vs. lymphoid organs, revealing a novel tissue-specific paradigm for the reactivation of memory CD8+ T cells.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Rockefeller University Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
TISSUE RESIDENT T CELLS
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CD8
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REACTIVATION
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APCS
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Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-09-06T15:12:25Z
dc.journal.volume
217
dc.journal.number
8
dc.journal.pagination
1-17
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Low, Jun Siong. University of Yale. School of Medicine; Estados Unidos
dc.description.fil
Fil: Farsakoglu, Yagmur. The Salk Institute for Biological Studies; Estados Unidos
dc.description.fil
Fil: Amezcua Vesely, Maria Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Sefik, Esen. University of Yale. School of Medicine; Estados Unidos
dc.description.fil
Fil: Kelly, Joseph B.. Stony Brook University; Estados Unidos
dc.description.fil
Fil: Harman, Christian C. D.. University of Yale. School of Medicine; Estados Unidos
dc.description.fil
Fil: Jackson, Ruaidhri. University of Yale. School of Medicine; Estados Unidos
dc.description.fil
Fil: Shyer, Justin A.. University of Yale. School of Medicine; Estados Unidos
dc.description.fil
Fil: Jiang, Xiaodong. University of Yale. School of Medicine; Estados Unidos
dc.description.fil
Fil: Cauley, Linda S.. University of Connecticut; Estados Unidos
dc.description.fil
Fil: Flavell, Richard A.. University of Yale. School of Medicine; Estados Unidos
dc.description.fil
Fil: Kaech, Susan M.. University of Yale. School of Medicine; Estados Unidos
dc.journal.title
Journal of Experimental Medicine
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://rupress.org/jem/article/doi/10.1084/jem.20192291/151854/Tissueresident-memory-T-cell-reactivation-by
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1084/jem.20192291
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