Artículo
Intestinal microbiota regulates tryptophan metabolism following oral infection with Toxoplasma gondii
Santos, Liliane M.; Commodaro, Alessandra G.; Vasquez, Alicia R. R.; Kohlhoff, Markus; de Paula Guerra, Daniel A.; Coimbra, Roney S.; Martins Filho, Olindo A.; Teixeira Carvalho, Andrea; Rizzo, Luiz V.; Vieira, Leda Q.; Serra, Horacio Marcelo
Fecha de publicación:
04/2020
Editorial:
Wiley Blackwell Publishing, Inc
Revista:
Parasite Immunology
ISSN:
0141-9838
e-ISSN:
1365-3024
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The intestinal microbiota plays an important role in modulating host immune responses. Oral Toxop/asma gondii infection can promote intestinal inflammation in certain mice strains. The 1DO-AhR axis may control tryptophan (Trp) metabolism constituting an important immune regulatory mechanism in inflammatory settings. Aims: In the present study, we investigated the role of the intestinal microbiota on Trp metabolism during oral infection with T gondii. Methods and results: Mice were treated with antibiotics for four weeks and then infected with T gondii by gavage. Histopathology and immune responses were evaluated 8 days after infection. We found that depletion of intestinal microbiota by antibiotics contributed to resistance against T gondii infection and led to reduced expression of AhR on dendritic and Treg cells. Mice depleted of Gram-negative bacteria presented higher levels of systemic Trp, downregulation of AhR expression and increased resistance to infection whereas depletion of Gram-positive bacteria did not affect susceptibility or expression of AhR on immune cells. Conclusion: Our findings indicate that the intestinal microbiota can control Trp availability and provide a link between the AhR pathway and host-microbiota interaction in acute infection with T gondii.
Palabras clave:
T GONDII
,
MICROBIOTA
,
ACUTE IMMUNE RESPONSE
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Articulos(CIBICI)
Articulos de CENTRO DE INV.EN BIOQUI.CLINICA E INMUNOLOGIA
Articulos de CENTRO DE INV.EN BIOQUI.CLINICA E INMUNOLOGIA
Citación
Santos, Liliane M.; Commodaro, Alessandra G.; Vasquez, Alicia R. R.; Kohlhoff, Markus; de Paula Guerra, Daniel A.; et al.; Intestinal microbiota regulates tryptophan metabolism following oral infection with Toxoplasma gondii; Wiley Blackwell Publishing, Inc; Parasite Immunology; 42; 9; 4-2020; 1-13
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