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dc.contributor.author
Olivella, Mónica Susana
dc.contributor.author
Lhez, Lucia
dc.contributor.author
Pappano, Nora Beatriz
dc.contributor.author
Debattista, Nora Beatriz
dc.date.available
2022-05-31T20:52:11Z
dc.date.issued
2008-10
dc.identifier.citation
Olivella, Mónica Susana; Lhez, Lucia; Pappano, Nora Beatriz; Debattista, Nora Beatriz; Effects of dimethylformamide and l-menthol permeation enhancers on transdermal delivery of quercetin; Informa Healthcare; Pharmaceutical Development and Technology; 12; 5; 10-2008; 481-484
dc.identifier.issn
1083-7450
dc.identifier.uri
http://hdl.handle.net/11336/158621
dc.description.abstract
In this work a feasibility study of transdermal delivery system for quercertin (Q) in carbopol gel through abdominal hairless pig skin in vitro was performed. Dimethylformamide (DMF) and L-menthol (M) were selected as enhancers. Permeation experiences were carried out by using Franz-type diffusion cells. Phosphate saline buffer (pH 7.4) was used in the receptor compartments. All the system was maintained at 32 ± 0.5°C with a circulating water jacket and magnetic stirring (180 rpm). Samples were analysed by UV-VIS spectrophotometer at 255 nm. Flux (Jm) values, permeation (P) and diffusion (D) coefficients were obtained. Results of Q in CG permeation experiences with different percentages of DMF and M showed that 16.7% DMF and 1.95% L-menthol enhancers were the best quantities for the system tested. Enhancer effect can be attributed to direct action on membrane structure by promoting its distension. Therefore, enhancer substitutes for water in pores, improving active principal permeation through pig skin. M significantly increases Q permeation about 17 times higher than control. The results of permeation experiments with M and DMF using the same enhancer concentration (1.42%) conclude that M action is 9 times higher than DMF, approximately, indicating that M is an effective enhancer for a transdermal therapeutic system of Q in CG as vehicle.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Informa Healthcare
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
QUERCETIN
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TRANSDERMAL DELIVERY
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HAIRLESS PIG SKIN
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PERMEATION ENHANCER
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Farmacología y Farmacia
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Effects of dimethylformamide and l-menthol permeation enhancers on transdermal delivery of quercetin
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-05-20T15:07:36Z
dc.identifier.eissn
1097-9867
dc.journal.volume
12
dc.journal.number
5
dc.journal.pagination
481-484
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Olivella, Mónica Susana. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química. Área de Química Física; Argentina
dc.description.fil
Fil: Lhez, Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química. Área de Química Física; Argentina
dc.description.fil
Fil: Pappano, Nora Beatriz. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química. Área de Química Física; Argentina
dc.description.fil
Fil: Debattista, Nora Beatriz. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química. Área de Química Física; Argentina
dc.journal.title
Pharmaceutical Development and Technology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.1080/10837450701481207
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1080/10837450701481207
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