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dc.contributor.author
Diaz, Silvina Laura
dc.contributor.other
Maroteaux, Luc
dc.contributor.other
Monassier, Laurent
dc.date.available
2022-05-30T17:17:23Z
dc.date.issued
2021
dc.identifier.citation
Diaz, Silvina Laura; 5-HT2B Receptors and Antidepressants; Springer; 2021; 1-401
dc.identifier.isbn
978-3-030-55919-9
dc.identifier.uri
http://hdl.handle.net/11336/158499
dc.description.abstract
Serotonin (5-Hydroxytryptamine, 5-HT) is a neurotransmitter involved in many psychiatric diseases including depression. The serotonergic neurons that innervate forebrain originate predominantly from the rostral cell group of neurons in the dorsal raphe nucleus (DRN). These neurons express the serotonergic markers tryptophan hydroxylase (TPH2), and serotonin transporter (SERT), and also the negative autoreceptors, 5-HT1A and 5-HT1B, whose expression is restricted to somatodendritic compartments of serotonergic neurons, and to axonal terminals, respectively. The 5-HT1A autoreceptor activation elicits an outward current carried through G protein-coupled inwardly-rectifying potassium channels (GIRK) of the Kir3 family leading to membrane hyperpolarization and inhibition of serotonergic neuron fring [4]. The presence of synaptic vesicles in dendrites of serotonergic neurons led to the suggestion that autoinhibition is mediated via dendritic release of 5-HT, for review see. However, activity of serotonin DRN neurons can also be positively modulated by 5-HT2A/2B/2C receptors triggering directly or indirectly inward currents [6–10]. Upon electrical stimulation of leech serotonergic neurons, transmembrane Ca2+ entry through L-type channels frst evokes an early dendritic exocytosis; subsequently, the released serotonin activates dendritic 5-HT2 autoreceptors coupled to Gq and phospholipase C, resulting in a positive feedforward loop that maintains sustained exocytosis. It has thus been proposed that DRN neurons can display responses ranging from inhibition to excitation depending on a balance of functional 5-HT1A and 5-HT2 receptors.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights
Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
5-HT
dc.subject
Depression
dc.subject
Fluoxetine
dc.subject
Mice
dc.subject.classification
Neurociencias
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
5-HT2B Receptors and Antidepressants
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/bookPart
dc.type
info:ar-repo/semantics/parte de libro
dc.date.updated
2022-05-17T16:58:28Z
dc.journal.pagination
1-401
dc.journal.pais
Suiza
dc.description.fil
Fil: Diaz, Silvina Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/chapter/10.1007/978-3-030-55920-5_21#DOI
dc.conicet.paginas
401
dc.source.titulo
5-HT2B Receptors: From Molecular Biological to Clinical Applications
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