Melatonin, gastrointestinal protection and oxidative stress

Abstract

We have tried to summarize the actions of melatonin (MEL) in different organs ofthe GIT and the potential usefulness as a drug to ameliorate or cure a variety of gastrointestinal disorders. A brief description of MEL receptors and their localization throughout the GIT is also presented. Analyses of experimental and clinical trials for healing or protection of gastrointestinal disorders, such as reflux esophagitis, peptic ulcers, ulcerative colitis, intestinal ischemia/reperfusion and others are performed. Finally, the effects of MEL treatment on the intestinal Ca2+ absorption under conditions of oxidative stress are discussed.