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Artículo

Information capacity and robustness of encoding in the medial prefrontal cortex are modulated by the bioavailability of serotonin and the time elapsed from the cue during a reward-driven task

Pereyra, Armando EzequielIcon ; Mininni, Camilo JuanIcon ; Zanutto, Bonifacio SilvanoIcon
Fecha de publicación: 07/2021
Editorial: Nature Publishing Group
Revista: Scientific Reports
e-ISSN: 2045-2322
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ingeniería Eléctrica, Ingeniería Electrónica e Ingeniería de la Información; Otros Tópicos Biológicos; Neurociencias

Resumen

Serotonin (5-HT) is a key neuromodulator of medial prefrontal cortex (mPFC) functions. Pharmacological manipulation of systemic 5-HT bioavailability alters the electrical activity of mPFC neurons. However, 5-HT modulation at the population level is not well characterized. In the present study, we made single neuron extracellular recordings in the mPFC of rats performing an operant conditioning task, and analyzed the effect of systemic administration of fluoxetine (a selective serotonin reuptake inhibitor) on the information encoded in the firing activity of the neural population. Chronic (longer than 15 days), but not acute (less than 15 days), fluoxetine administration reduced the firing rate of mPFC neurons. Moreover, fluoxetine treatment enhanced pairwise entropy but diminished noise correlation and redundancy in the information encoded, thus showing how mPFC differentially encodes information as a function of 5-HT bioavailability. Information about the occurrence of the reward-predictive stimulus was maximized during reward consumption, around 3 to 4 s after the presentation of the cue, and it was higher under chronic fluoxetine treatment. However, the encoded information was less robust to noise corruption when compared to control conditions.
Palabras clave: PREFRONTAL CORTEX , ENTROPY , FLUOXETINE , OPERANT CONDITINING , SEROTONIN , ROBUST ENCODING
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/158215
URL: https://www.nature.com/articles/s41598-021-93313-6
DOI: http://dx.doi.org/10.1038/s41598-021-93313-6
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Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Pereyra, Armando Ezequiel; Mininni, Camilo Juan; Zanutto, Bonifacio Silvano; Information capacity and robustness of encoding in the medial prefrontal cortex are modulated by the bioavailability of serotonin and the time elapsed from the cue during a reward-driven task; Nature Publishing Group; Scientific Reports; 11; 1388; 7-2021; 1-13
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