Artículo
Radiosensitivity of radiotherapy patients: The effect of individual DNA repair capacity
Fecha de publicación:
07/2021
Editorial:
Elsevier Science
Revista:
Mutation Research. Genetic Toxicology And Environmental Mutagenesis
ISSN:
1383-5718
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Individual radiosensitivity is a critical problem in radiotherapy because of the treatment restrictions it imposes. We have tested whether induction/repair of genomic lesions correlates with the acute cutaneous effects of radiotherapy. Peripheral blood samples of 56 healthy volunteers and 18 patients with breast cancer were studied. DNA damage and DNA repair capacity were assessed in vitro (alkaline comet assay). Patients without skin reaction did not show significant differences from healthy individuals, with respect to either initial or radiation-induced DNA damage. Similar DNA repair kinetics, fitting a decreasing exponential response, were observed in both groups, and there were no significant differences in residual genotoxic damage. In contrast, patients exhibiting acute side effects showed significantly lower DNA repair ability and significantly more residual damage, compared to patients without radiotoxicity. This approach may help to identify patients who are at greater risk of radiotherapy side effects. However, many other factors, such as dosimetry, irradiated volume, and lifestyle should also be considered in the evaluation of individual radiosensitivity.
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IGEVET)
Articulos de INST.DE GENETICA VET ING FERNANDO NOEL DULOUT
Articulos de INST.DE GENETICA VET ING FERNANDO NOEL DULOUT
Citación
Ocolotobiche, Eliana Evelina; Dauder, Ricard Marcos; Güerci, Alba Mabel; Radiosensitivity of radiotherapy patients: The effect of individual DNA repair capacity; Elsevier Science; Mutation Research. Genetic Toxicology And Environmental Mutagenesis; 867; 503371; 7-2021; 1-5
Compartir
Altmétricas