Artículo
Increased Cholesteryl Ester Transfer Protein and Lipoprotein-Associated Phospholipase A2 Activities in Children and Adolescents Presenting High Triglyceride/High-Density Lipoprotein Cholesterol (TG/HDL-C) Ratio
Ferraro, Florencia; Martín, Maximiliano; Verona, Julian; Gilligan, Lisandro; Verona, Maria Florencia; Botta, Eliana Elizabeth
; Tetzlaff, Walter Francisco
; Lozano Chiappe, Ezequiel Silvano; Boero, Laura; Brites, Walter Fernando
Fecha de publicación:
07/2021
Editorial:
All India Inst Medical Sciences
Revista:
Indian Journal Of Pediatrics
ISSN:
0019-5456
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Objective: To explore the association between Triglyceride/High-density lipoprotein cholesterol (TG/HDL-C) index and these enzymes and proteins in a pediatric population. Methods: Children and adolescents (7–14 y old) were recruited (n = 150) and anthropometric data were registered. Glucose, TG, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), HDL-C plus cholesteryl ester transfer protein (CETP), lipoprotein-associated phospholipase A2 (Lp-PLA2) and paraoxonase 1 (PON1) activities were determined. Results: Twenty-five individuals presented TG/HDL-C ratio ≥ 3.0. These individuals exhibited higher TG [164 (126–186) vs. 65 (48–72) mg/dL; p < 0.01] CETP [250 (232–263) vs. 223 (193–237)% mL/min; p < 0.01] and Lp-PLA2 (4.5 ± 1.9 vs. 3.5 ± 1.3; p < 0.05) plus lower HDL-C [41 (37–49) vs. 52 (48–62) mg/dL; p < 0.01] compared to an age-matched group with TG/HDL-C < 3.0. TG/HDL-C ratio was associated to CETP (p < 0.01) and Lp-PLA2 (p < 0.05). Multiple lineal regression analyses showed TG/HDL-C index as an independent predictor of CETP (r2 = 0.29; beta = 0.49; p < 0.01) and Lp-PLA2 (r2 = 0.21; beta = 0.32; p < 0.05) activities. Conclusion: Children and adolescents with TG/HDL-C ≥ 3.0 presented a more atherogenic lipid profile and higher CETP and Lp-PLA2 activities, which would indicate alterations in lipoprotein metabolism and quality.
Palabras clave:
CETP
,
INSULIN RESISTANCE
,
LP-PLA2
,
TRIGLYCERIDES/HDL-C RATIO
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Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Ferraro, Florencia; Martín, Maximiliano; Verona, Julian; Gilligan, Lisandro; Verona, Maria Florencia; et al.; Increased Cholesteryl Ester Transfer Protein and Lipoprotein-Associated Phospholipase A2 Activities in Children and Adolescents Presenting High Triglyceride/High-Density Lipoprotein Cholesterol (TG/HDL-C) Ratio; All India Inst Medical Sciences; Indian Journal Of Pediatrics; 88; 12; 7-2021; 1180-1186
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