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dc.contributor.author
Bozzini, Carlos Eduardo Jose
dc.contributor.author
Champin, Graciela Monica
dc.contributor.author
Bozzini, Clarisa
dc.contributor.author
Alippi, Rosa Maria
dc.date.available
2017-04-27T19:54:33Z
dc.date.issued
2014-03
dc.identifier.citation
Bozzini, Carlos Eduardo Jose; Champin, Graciela Monica; Bozzini, Clarisa; Alippi, Rosa Maria; Gestational and early postnatal exposure to simulated high altitude does not modify postnatal body mass growth trajectory in the rat; Mary Ann Liebert Inc; High Altitude Medicine & Biology; 15; 3; 3-2014; 418-421
dc.identifier.issn
1527-0297
dc.identifier.uri
http://hdl.handle.net/11336/15807
dc.description.abstract
Postnatal hypoxia blunts body mass growth. It is also known that the quality of the fetal environment can influence the subsequent adult phenotype. The main purpose of the study was to determine whether gestational hypoxia and early postnatal hypoxia are able to blunt growth when the offspring is raised under normoxia. Hypobaric hypoxia was induced in simulated high altitude (SHA) chambers in which air was maintained at 380 mmHg (5450 m). Mature Sprague-Dawley rats of both sexes were divided in normoxic (NX) and hypoxic (HX) groups and, in the case of the HX group, maintained for 1 month at 5450 m. Mating was then allowed under NX or HX conditions. Offspring were NX-NX, NX-HX, HX-HX, or HX-NX: the first term indicates NX or HX during both gestation and the first 30 days of life; the second term indicates NX or HX during postnatal life between days 30 and 133. Body mass (g) was measured periodically and body mass growth rate (BMGR, g/d) was estimated between days 33 and 65 of postnatal life. Results can be summarized as follows: 1) BM was significantly higher in NX than in HX rats at weaning; 2) BMGR was not significantly different between NX-NX and HX-NX rats, and between HX-HX and NX-HX animals; and 3) BMGR was significantly higher in rats living under NX conditions than in those living under HX conditions during postnatal life. Data suggest that that hypobaric hypoxia during gestational and early postnatal development of rats does not alter the regulation of body mass growth in rats when compared to that seen under sea-level conditions.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Mary Ann Liebert Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Body Mass
dc.subject
Developmental Phenotype
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Growth
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Hypoxia
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Simulated High Altitude
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Fisiología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Gestational and early postnatal exposure to simulated high altitude does not modify postnatal body mass growth trajectory in the rat
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-04-26T14:13:10Z
dc.identifier.eissn
1557-8682
dc.journal.volume
15
dc.journal.number
3
dc.journal.pagination
418-421
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Bozzini, Carlos Eduardo Jose. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Champin, Graciela Monica. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Bozzini, Clarisa. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina
dc.description.fil
Fil: Alippi, Rosa Maria. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
High Altitude Medicine & Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1089/ham.2014.1022
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://online.liebertpub.com/doi/abs/10.1089/ham.2014.1022
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175034/
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